The Combined Effects of Cr(III) Supplementation and Iron Deficiency on the Copper and Zinc Status in Wistar Rats

• Published in: Biological trace element research Vol. 190; no. 2; pp. 414 - 424
• Main Author: Staniek, Halina
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.08.2019; Springer Nature B.V
• Subjects: Absorption spectroscopy; Anaemia; Anemia; Anemia, Iron-Deficiency - drug therapy; Anemia, Iron-Deficiency - metabolism; Animals; Atomic absorption analysis; atomic absorption spectrometry; Atomic absorption spectroscopy; Biochemistry; Biomedical and Life Sciences; Biotechnology; Body Weight; Chromium; Chromium Compounds - administration & dosage; Chromium Compounds - therapeutic use; Copper; Copper - administration & dosage; Copper - therapeutic use; Diabetes mellitus; Dietary Supplements; Disease Models, Animal; Dose-Response Relationship, Drug; Eating - drug effects; Female; Females; Ferric Compounds - administration & dosage; Ferric Compounds - therapeutic use; Interactions; Iron; Iron deficiency; laboratory animals; Life Sciences; Metabolic disorders; nutrient deficiencies; Nutrient deficiency; Nutrition; Oncology; patients; Rats; Rats, Wistar; Rodents; Spectral analysis; Spectrometry; Structure-Activity Relationship; therapeutics; Trace elements; Trivalent chromium; Zinc; Zinc - administration & dosage; Zinc - therapeutic use; Rats; Copper; Iron deficiency; Chromium(III) propionate complex; Zinc
• ISSN: 0163-4984; 1559-0720; 1559-0720
• DOI: 10.1007/s12011-018-1568-7

The aim of the study was to assess the combined effects of chromium(III) supplementation and iron deficiency on the copper (Cu) and zinc (Zn) status in female rats. The Cr, Fe, Cu and Zn dietary and tissular levels were measured by Atomic Absorption Spectrometry (AAS) method. The data show that chromium(III) supplementation compensated for the negative effects of Fe deficiency on the Cu content but it deepened the effect on Zn levels in the female rats. Detailed data on the status of trace elements and their interactions in healthy subjects and patients with metabolic disorders (e.g. anaemia, diabetes mellitus) are strongly required for effective nutritional and therapeutic strategies.