Highly Fermentable Fiber Alters Fecal Microbiota and Mitigates Swine Dysentery Induced by Brachyspira hyodysenteriae

• Published in: Animals (Basel) Vol. 11; no. 2; p. 396
• Main Authors: Helm, Emma T, Gabler, Nicholas K, Burrough, Eric R
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 04.02.2021; MDPI
• Subjects: Antiinfectives and antibacterials; Brachyspira; Brachyspira hyodysenteriae; Colon; Deoxyribonucleic acid; Diet; Dietary fiber; Disease control; DNA; Dysentery; Etiology; Fecal microflora; Feces; Feeds; fermentable fiber; Fibers; Health services; Hogs; Infections; Inoculation; insoluble fiber; Laboratories; Large intestine; Livestock; Microbiota; Microorganisms; nutrition; Pathogens; pig; Relative abundance; Starch; Swine; Swine dysentery; Waterborne diseases; United States > US; Iowa; Brachyspira hyodysenteriae; microbiota; nutrition; fermentable fiber; insoluble fiber; pig
• ISSN: 2076-2615; 2076-2615
• DOI: 10.3390/ani11020396

is an etiological agent of swine dysentery (SD). Diet fermentability plays a role in development of SD, but the mechanism(s) of action are largely unknown. Thus, this study aimed to determine whether replacing lowly fermentable fiber with highly fermentable fiber would mitigate a 42 d challenge. Thirty-nine barrows were allocated to dietary treatment groups: (1) 20% corn distillers dried grain with solubles (DDGS), 0% beet pulp (BP) or resistant starch (RS; lowly fermentable fiber (LFF)); (2) 10% DDGS, 5% BP, 5% RS (medium fermentable fiber (MFF)); and (3) 0% DDGS, 10% BP, 10% RS (highly fermentable fiber (HFF)). On day post inoculation 0, pigs were inoculated with . Overall, 85% LFF pigs developed clinical SD, 46% of MFF pigs developed SD, and 15% of HFF pigs developed SD ( < 0.05). Overall average daily gain (ADG) differed among all treatments ( < 0.001), with LFF pigs having the lowest ADG. For HFF pigs, ADG was 37% greater than LFF pigs ( < 0.001) and 19% greater than MFF pigs ( = 0.037). The LFF diet had greater relative abundance of and . Further, microbiota of pigs that developed SD had enriched . Collectively, replacing DDGS with highly fermentable fiber reduced clinical SD, improved performance, and modulated fecal microbiota during challenge.