Recombinant PhpA Protein, a Unique Histidine Motif-Containing Protein from Streptococcus pneumoniae, Protects Mice against Intranasal Pneumococcal Challenge

• Published in: Infection and Immunity Vol. 69; no. 6; pp. 3827 - 3836
• Main Authors: YING ZHANG, MASI, Amy W, BARNIAK, Vicki, MOUNTZOUROS, Ken, HOSTETTER, Margaret K, GREEN, Bruce A
• Format: Journal Article
• Language: English
• Published: Washington, DC American Society for Microbiology 01.06.2001
• Subjects: Administration, Intranasal; Animals; Antibodies, Bacterial - blood; Bacterial diseases; Bacterial Proteins - genetics; Bacterial Proteins - immunology; Bacteriology; Biological and medical sciences; Endopeptidases - chemistry; Endopeptidases - genetics; Endopeptidases - immunology; Endopeptidases - metabolism; Experimental bacterial diseases and models; Fundamental and applied biological sciences. Psychology; Histidine - chemistry; Humans; Immunization; Infectious diseases; Male; Medical sciences; Mice; Mice, Inbred CBA; Microbial Immunity and Vaccines; Microbiology; Molecular Sequence Data; Nasopharynx - microbiology; Otitis Media - microbiology; Otitis Media - prevention & control; PhpA protein; Pneumococcal Infections - microbiology; Pneumococcal Infections - prevention & control; Pneumococcal Vaccines - immunology; Recombinant Proteins - genetics; Recombinant Proteins - immunology; Recombinant Proteins - metabolism; Sequence Analysis, DNA; Streptococcal Vaccines; Streptococcus pneumoniae; Streptococcus pneumoniae - immunology; Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies; Still disease; Middle ear disease; Diseases of the osteoarticular system; Systemic; Histidine; Antigenicity; Streptococcal infection; Systemic disease; Bacteria; Micrococcales; ENT disease; Recombinant protein; Serotype; Anthropogenic factor; Human; Rodentia; Vaccine; Protein A; Streptococcus pneumoniae; Infection; Streptococcaceae; Vertebrata; Mammalia; Mouse; Aminoacid; Bacteriosis; Otitis media; Conjugation
• ISSN: 0019-9567; 1098-5522
• DOI: 10.1128/IAI.69.6.3827-3836.2001

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