Contractility of Right Ventricular Myocardium in Male and Female Rats during Physiological and Pathological Hypertrophy

Sex differences in the morphogenesis and adaptation of the mechanisms controlling myocardium contractility during physiological and pathological hypertrophy of the right ventricle were demonstrated in mature rats. The study revealed sex-dependent effects of physiological and pathological cardiac hyp...

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Published inBulletin of experimental biology and medicine Vol. 162; no. 3; pp. 303 - 305
Main Authors Protsenko, Yu. L., Balakin, A. A., Kuznetsov, D. A., Kursanov, A. G., Lisin, R. V., Mukhlynina, E. A., Lookin, O. N.
Format Journal Article
LanguageEnglish
Published New York Springer US 2017
Springer
Springer Nature B.V
Subjects
Animals
Biomedical and Life Sciences
Biomedicine
Cardiomegaly - chemically induced
Cardiomegaly - physiopathology
Cardiomyocytes
Cell Biology
Cell Size
Female
Gender differences
Heart
Heart - drug effects
Heart - physiology
Heart - physiopathology
Heart diseases
Heart hypertrophy
Heart Ventricles - drug effects
Heart Ventricles - physiopathology
Hypertrophy
Internal Medicine
Isometric Contraction - drug effects
Isometric Contraction - physiology
Isotonic Contraction - drug effects
Isotonic Contraction - physiology
Laboratory Medicine
Male
Monocrotaline - toxicity
Morphogenesis
Muscle contraction
Myocardial Contraction - drug effects
Myocardial Contraction - physiology
Myocardium
Myocytes, Cardiac - drug effects
Myocytes, Cardiac - pathology
Myocytes, Cardiac - physiology
Pathology
Physiological aspects
Physiology
Rats
Rats, Wistar
Rodents
Sex Characteristics
Sex differences
Swimming
Velocity
Ventricle
rat myocardium
pathological cardiac hypertrophy
physiological cardiac hypertrophy
isometric contraction
isotonic contraction
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Summary:Sex differences in the morphogenesis and adaptation of the mechanisms controlling myocardium contractility during physiological and pathological hypertrophy of the right ventricle were demonstrated in mature rats. The study revealed sex-dependent effects of physiological and pathological cardiac hypertrophy on the coefficient of variation of the cardiomyocyte diameter, length-dependent control of the contractile force, and the maximum velocity of isotonic shortening.
Bibliography:ObjectType-Article-1
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ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-017-3600-x