Melanin-concentrating hormone in the human brain

The presence of human melanin-concentrating hormone (MCH) was studied in the human brain by radioimmunoassay and immunocytochemistry. Immunoreactive MCH concentrations in the human brain ranged from 0.07 to 19.7 pmol/g wet weight. High performance liquid chromatography of the hypothalamus showed a l...

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Published inPeptides (New York, N.Y. : 1980) Vol. 14; no. 3; pp. 643 - 646
Main Authors Mouri, Toraichi, Takahashi, Kazuhiro, Kawauchi, Hiroshi, Sone, Masahiko, Totsune, Kazuhito, Murakami, Osamu, Itoi, Keiichi, Ohneda, Makoto, Sasano, Hironobu, Sasano, Nobuaki
Format Journal Article
LanguageEnglish
Published New York, NY Elsevier Inc 01.05.1993
Elsevier Science
Subjects
Aged
Biological and medical sciences
Brain
Brain Chemistry
Chromatography
Chromatography, High Pressure Liquid
Female
Fundamental and applied biological sciences. Psychology
Human
Humans
Hypothalamic Hormones
Hypothalamus
Hypothalamus. Hypophysis. Epiphysis. Urophysis
Immunocytochemistry
Immunohistochemistry
Male
Melanin-concentrating hormone
Melanins - analysis
Middle Aged
Morphology. Functional localizations
Pituitary Hormones - analysis
Radioimmunoassay
Vertebrates: endocrinology
Human
Brain
Melanin-concentrating hormone
Immunocytochemistry
Radioimmunoassay
Hypothalamus
Chromatography
Central nervous system
Melanin concentrating hormone
Neuropeptide
Brain (vertebrata)
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Summary:The presence of human melanin-concentrating hormone (MCH) was studied in the human brain by radioimmunoassay and immunocytochemistry. Immunoreactive MCH concentrations in the human brain ranged from 0.07 to 19.7 pmol/g wet weight. High performance liquid chromatography of the hypothalamus showed a large immunoreactive peak in the position of human/rat MCH, which was eluted 9 min later than that of salmon MCH. Free-floating sections (40 μm) of the hypothalamus were immunostained. Positive MCH immunostaining was found in perifornical, tuberomammillary, and posterior nuclei. Numerous MCH-immunoreactive nerve fibers were observed throughout the hypothalamus. The presence of high concentrations of MCH in the human brain, in particular in the hypothalamus, suggests that MCH is a neurotransmitter, a neuromodulator, or a neurohormone in man.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:0196-9781
1873-5169
DOI:10.1016/0196-9781(93)90158-D