Modic type I change may predict rapid progressive, deforming disc degeneration: a prospective 1-year follow-up study

Introduction This prospective magnetic resonance imaging (MRI) study in chronic low-back pain (CLBP) patients evaluated the natural course of degenerative lumbar spine changes in relation to Modic 1 type changes (M1) within 1 year. Materials and methods From 3,811 consecutive CLBP patients referred...

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Published inEuropean spine journal Vol. 21; no. 6; pp. 1135 - 1142
Main Authors Kerttula, Liisa, Luoma, Katariina, Vehmas, Tapio, Grönblad, Mats, Kääpä, Eeva
Format Journal Article
LanguageEnglish
Published Berlin/Heidelberg Springer-Verlag 01.06.2012
Springer Nature B.V
Subjects
Adult
Aged
Chronic Disease
Degeneration
Disease Progression
Female
Humans
Image Interpretation, Computer-Assisted
Intervertebral Disc Degeneration - complications
Intervertebral Disc Degeneration - pathology
Intervertebral discs
Low Back Pain - etiology
Low Back Pain - pathology
Lumbar Vertebrae - pathology
Magnetic Resonance Imaging
Male
Medicine
Medicine & Public Health
Middle Aged
Neurosurgery
Original
Original Article
Pain
Spine (lumbar)
Surgical Orthopedics
Young Adult
Modic change
Magnetic resonance imaging
Endplate lesion
Intervertebral disc
Degenerative disc disease
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Summary:Introduction This prospective magnetic resonance imaging (MRI) study in chronic low-back pain (CLBP) patients evaluated the natural course of degenerative lumbar spine changes in relation to Modic 1 type changes (M1) within 1 year. Materials and methods From 3,811 consecutive CLBP patients referred to lumbar spine MRI 54 patients with a large M1 were selected using strict exclusion criteria to exclude specific back disorders. Follow-up MRI was obtained within 11–18 months. Results At baseline M1 was associated with an adjacent endplate lesion in 96% of the cases. In follow-up, an unstable M1 was associated both with an increase of endplate lesions, decrease of disc height and change in disc signal intensity, most found at L4/5 or L5/S1. In disc spaces without M1, progression of degenerative changes was rare. Conclusion Endplate deformation, decreasing disc height and change of disc signal intensity appear essential features of accelerated degenerative process associated with M1.
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ISSN:0940-6719
1432-0932
DOI:10.1007/s00586-012-2147-9