The APC Gene in Turcot's Syndrome

To the Editor: Hamilton et al. (March 30 issue) 1 demonstrat-ed frequent mutations of the APC gene in patients with Tur-cot's syndrome and showed that medulloblastoma is the predominant brain tumor in families with that syndrome who have APC mutations. In most hereditary tumor syndromes, a germ...

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Bibliographic Details
Published inThe New England journal of medicine Vol. 333; no. 8; p. 524
Main Authors Yong, W H, Raffel, C, von Deimling, A, Louis, D N
Format Journal Article
LanguageEnglish
Published United States Massachusetts Medical Society 24.08.1995
Subjects
Adenomatous Polyposis Coli - genetics
Genes, APC
Germ-Line Mutation
Humans
Medulloblastoma - genetics
Syndrome
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Summary:To the Editor: Hamilton et al. (March 30 issue) 1 demonstrat-ed frequent mutations of the APC gene in patients with Tur-cot's syndrome and showed that medulloblastoma is the predominant brain tumor in families with that syndrome who have APC mutations. In most hereditary tumor syndromes, a germ-line mutation predisposes a family to a unique panoply of tumor types. In the corresponding sporadic tumors, the same gene is usually mutated on a somatic basis. 2 Thus, in the same issue of the Journal, Groden 3 raised the possibility that the APC gene may also be involved in sporadic medulloblastomas. We explored this hypothesis after . . .
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ISSN:0028-4793
1533-4406
DOI:10.1056/NEJM199508243330817