Toll-Like Receptors in Wound Healing: Location, Accessibility, and Timing

• Published in: Journal of investigative dermatology Vol. 132; no. 8; pp. 1955 - 1958
• Main Authors: Dasu, Mohan R., Rivkah Isseroff, R.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.08.2012; Elsevier Limited
• Subjects: Animals; Female; Gene Expression Regulation; Humans; Inflammation; Injuries; Male; Pathogens; Poly I-C - metabolism; Toll-Like Receptor 3 - metabolism; Toll-like receptors; Trauma; Wound Healing

Toll-like receptors (TLRs) are considered to be the first responders in the defense against invading pathogens. TLR engagement by ligands triggers inflammatory responses in injury and trauma, and thus can impair or contribute to the healing process, depending on TLRs' expression pattern, cellul...