Toll-Like Receptors in Wound Healing: Location, Accessibility, and Timing

Toll-like receptors (TLRs) are considered to be the first responders in the defense against invading pathogens. TLR engagement by ligands triggers inflammatory responses in injury and trauma, and thus can impair or contribute to the healing process, depending on TLRs' expression pattern, cellul...

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Bibliographic Details
Published inJournal of investigative dermatology Vol. 132; no. 8; pp. 1955 - 1958
Main Authors Dasu, Mohan R., Rivkah Isseroff, R.
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.08.2012
Elsevier Limited
Subjects
Animals
Female
Gene Expression Regulation
Humans
Inflammation
Injuries
Male
Pathogens
Poly I-C - metabolism
Toll-Like Receptor 3 - metabolism
Toll-like receptors
Trauma
Wound Healing
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Summary:Toll-like receptors (TLRs) are considered to be the first responders in the defense against invading pathogens. TLR engagement by ligands triggers inflammatory responses in injury and trauma, and thus can impair or contribute to the healing process, depending on TLRs' expression pattern, cellular localization, signaling, and deployment of inflammatory responses. Understanding these attributes could improve therapeutic strategies for treating chronic wounds.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
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ISSN:0022-202X
1523-1747
DOI:10.1038/jid.2012.208