SIRT6 in DNA repair, metabolism and ageing

. Ageing, or increased mortality with time, coupled with physiologic decline, is a nearly universal yet poorly understood biological phenomenon. Studies in model organisms suggest that two conserved pathways modulate longevity: DNA damage repair and Insulin/Igf1‐like signalling. In addition, homolog...

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Published inJournal of internal medicine Vol. 263; no. 2; pp. 128 - 141
Main Authors Lombard, D. B., Schwer, B., Alt, F. W., Mostoslavsky, R.
Format Journal Article Conference Proceeding
LanguageEnglish
Published Oxford, UK Blackwell Publishing Ltd 01.02.2008
Blackwell Science
Subjects
ageing
Aging - metabolism
Animals
Biological and medical sciences
DNA damage
DNA Repair - physiology
General aspects
Longevity
Medical sciences
metabolism
Mice
Mice, Knockout
Models, Biological
Phenotype
Sirtuins - metabolism
Medicine
DNA
Ageing
DNA damage
Lesion
Metabolism
DNA repair
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Summary:. Ageing, or increased mortality with time, coupled with physiologic decline, is a nearly universal yet poorly understood biological phenomenon. Studies in model organisms suggest that two conserved pathways modulate longevity: DNA damage repair and Insulin/Igf1‐like signalling. In addition, homologs of yeast Sir2 – the sirtuins – regulate lifespan in diverse organisms. Here, we focus on one particular sirtuin, SIRT6. Mice lacking SIRT6 develop a degenerative disorder that in some respects mimics models of accelerated ageing [Cell (2006) 124:315]. We discuss how sirtuins in general and SIRT6 specifically relate to other evolutionarily conserved pathways affecting ageing, and how SIRT6 might function to ensure organismal homeostasis and normal lifespan.
Bibliography:Present address: Department of Medicine, Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA
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Present address: Department of Medicine, Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA
ISSN:0954-6820
1365-2796
DOI:10.1111/j.1365-2796.2007.01902.x