Review article: gastric electrical stimulation for gastroparesis – physiological foundations, technical aspects and clinical implications
Summary Background Application of electrical stimulation to the gut, primarily the stomach, has rapidly advanced in the last two decades, from mostly animal studies to the clinical arena. Most studies focused on the use of electrical stimulation for gastroparesis, the only approved indication for s...
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Published in | Alimentary pharmacology & therapeutics Vol. 30; no. 7; pp. 681 - 694 |
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Main Authors | , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Oxford, UK
Blackwell Publishing Ltd
01.10.2009
Blackwell |
Subjects | |
Online Access | Get full text |
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Summary: | Summary
Background Application of electrical stimulation to the gut, primarily the stomach, has rapidly advanced in the last two decades, from mostly animal studies to the clinical arena. Most studies focused on the use of electrical stimulation for gastroparesis, the only approved indication for such intervention.
Aim To review the physiological basis of gastric electrical activity and the technical aspects and clinical outcome of gastric electrical stimulation (GES) for gastroparesis.
Methods PubMed search from 1966 to 2009, using gastroparesis and GES as search terms. Areas in focus were systematically reviewed.
Results The literature consists of open‐label studies, mostly from single centres, published in the last decade. Improvement in symptoms, quality of life and nutritional status was reported by most studies. Physiologically, stimulation parameters approved in clinical practice do not regulate gastric slow wave activity and have inconsistent effect on gastric emptying. The mechanism of action of GES is not fully known, but data support modulation of gastric biomechanical activity and afferent neural mechanisms.
Conclusions Gastric electrical stimulation is a helpful intervention in recalcitrant gastroparesis. Controlled studies and better understanding of mechanisms of action of electrical stimulation are needed to evaluate further the clinical utility of this intervention and to exploit its therapeutic potential better. |
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Bibliography: | This review is the proceeding of a symposium on gut electrical stimulation held at the 16th International Workshop on Electrogastrography, sponsored by the International Electrogastrography Society, in San Diego, in May 2008. ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1 |
ISSN: | 0269-2813 1365-2036 |
DOI: | 10.1111/j.1365-2036.2009.04082.x |