Removing the heart from the brain: compensation for the pulse artifact in the photon migration signal

Various factors, including variations in the concentration of hemoglobin, determine changes in the transparency of living tissue to near-infrared light. Hence, optical measures have been proposed as a noninvasive method for investigating regional changes in brain activity. However, the amount of nea...

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Bibliographic Details
Published inPsychophysiology Vol. 32; no. 3; p. 292
Main Authors Gratton, G, Corballis, P M
Format Journal Article
LanguageEnglish
Published United States 01.05.1995
Subjects
Adult
Algorithms
Blood Pressure - physiology
Brain - blood supply
Heart Rate - physiology
Humans
Infrared Rays
Male
Photoplethysmography - instrumentation
Pulse - physiology
Regression Analysis
Signal Processing, Computer-Assisted - instrumentation
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Summary:Various factors, including variations in the concentration of hemoglobin, determine changes in the transparency of living tissue to near-infrared light. Hence, optical measures have been proposed as a noninvasive method for investigating regional changes in brain activity. However, the amount of near-infrared light traversing a region of the head is also influenced by the periodic changes in blood pressure that occur during the cardiac cycle (pulse). These large changes may obscure smaller, localized events associated with brain activity. We developed a least-squares regression algorithm for compensating for the artifact introduced by the pulse. This procedure takes into account beat-to-beat variability in heart rate and differences in the shape of the pulse among subjects and among recording conditions.
ISSN:0048-5772
DOI:10.1111/j.1469-8986.1995.tb02958.x