Dynamics of infection by leukotoxic strains of Actinobacillus actinomycetemcomitans in juvenile periodontitis

Juvenile periodontitis is associated with a high incidence of infection by Actinobacillus actinomycetemcomitans (Aa). The data presented indicate that the ability of Aa to destroy human PMNs is altered during the course of infection. Leukotoxic strains of Aa are characteristically found in isolates...

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Bibliographic Details
Published inJournal of clinical periodontology Vol. 13; no. 4; p. 330
Main Authors Tsai, C C, Taichman, N S
Format Journal Article
LanguageEnglish
Published United States 01.04.1986
Subjects
Actinobacillus - immunology
Actinobacillus - physiology
Actinobacillus Infections - physiopathology
Adolescent
Adult
Age Factors
Aggressive Periodontitis - immunology
Aggressive Periodontitis - microbiology
Aggressive Periodontitis - physiopathology
Antibodies, Bacterial - analysis
Child
Cytotoxins - immunology
Cytotoxins - pharmacology
Humans
Leukocytes - drug effects
Leukocytes - immunology
Periodontal Diseases - microbiology
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Summary:Juvenile periodontitis is associated with a high incidence of infection by Actinobacillus actinomycetemcomitans (Aa). The data presented indicate that the ability of Aa to destroy human PMNs is altered during the course of infection. Leukotoxic strains of Aa are characteristically found in isolates obtained from younger patients (6-12 years of age) but not in older subjects (13-25 years old). This suggests that the leukotoxin may be more important during early as opposed to more advanced phases of juvenile periodontitis.
ISSN:0303-6979
DOI:10.1111/j.1600-051x.1986.tb02231.x