Two missense mutations, E123Q and K151E, identified in the ERG11 allele of an azole-resistant isolate of Candida kefyr recovered from a stem cell transplant patient for acute myeloid leukemia

We report on the first cloning and nucleotide sequencing of an ERG11 allele from a clinical isolate of Candida kefyr cross-resistant to azole antifungals. It was recovered from a stem cell transplant patient, in an oncohematology unit exhibiting unexpected high prevalence of C. kefyr. Two amino acid...

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Published inMedical mycology case reports Vol. 5; no. C; pp. 12 - 15
Main Authors Couzigou, Célia, Gabriel, Frédéric, Biteau, Nicolas, Fitton-Ouhabi, Valérie, Noël, Thierry, Accoceberry, Isabelle
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier 01.07.2014
Subjects
Azole resistance
Candida kefyr
ERG11
Kluyveromyces marxianus
Single nucleotide polymorphism
ERG11
Kluyveromyces marxianus
Single nucleotide polymorphism
Azole resistance
Candida kefyr
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Summary:We report on the first cloning and nucleotide sequencing of an ERG11 allele from a clinical isolate of Candida kefyr cross-resistant to azole antifungals. It was recovered from a stem cell transplant patient, in an oncohematology unit exhibiting unexpected high prevalence of C. kefyr. Two amino acid substitutions were identified: K151E, whose role in fluconazole resistance was already demonstrated in Candida albicans, and E123Q, a new substitution never described so far in azole-resistant Candida yeast.
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ISSN:2211-7539
2211-7539
DOI:10.1016/j.mmcr.2014.04.002