A Tale of Two Genes: Microglial Apoe and Trem2

Microglial cell function is implicated in the etiology of Alzheimer’s disease by human genetics. In this issue of Immunity, Krasemann et al. (2017) describe a gene expression signature associated with an APOE- and TREM2-dependent response of microglia to brain tissue damage that accumulates in aging...

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Bibliographic Details
Published inImmunity (Cambridge, Mass.) Vol. 47; no. 3; pp. 398 - 400
Main Authors Pimenova, Anna A., Marcora, Edoardo, Goate, Alison M.
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 19.09.2017
Elsevier Limited
Subjects
Aging
Alzheimer Disease
Amyotrophic lateral sclerosis
Apolipoprotein E
Apolipoproteins E
Bioaccumulation
Brain
Brain damage
Brain injury
Damage accumulation
Disease
Etiology
Gene expression
Genetics
Genomics
Homeostasis
Humans
Microglia
Microglia - immunology
Multiple sclerosis
Neurodegeneration
Neurons
Rodents
Studies
Therapeutic targets
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Summary:Microglial cell function is implicated in the etiology of Alzheimer’s disease by human genetics. In this issue of Immunity, Krasemann et al. (2017) describe a gene expression signature associated with an APOE- and TREM2-dependent response of microglia to brain tissue damage that accumulates in aging and disease, defining an axis that might be amenable to therapeutic targeting. Microglial cell function is implicated in the etiology of Alzheimer’s disease by human genetics. In this issue of Immunity, Krasemann et al. (2017) describe a gene expression signature associated with an ApoE- and Trem2-dependent response of microglia to brain tissue damage that accumulates in aging and disease, defining an axis that might be amenable to therapeutic targeting.
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ISSN:1074-7613
1097-4180
1097-4180
DOI:10.1016/j.immuni.2017.08.015