Studies on medicinal plants of Ivory Coast: Investigation of Sida acuta for in vitro antiplasmodial activities and identification of an active constituent

• Published in: Phytomedicine (Stuttgart) Vol. 11; no. 4; pp. 338 - 341
• Main Authors: Banzouzi, J.-T., Prado, R., Menan, H., Valentin, A., Roumestan, C., Mallié, M., Pelissier, Y., Blache, Y.
• Format: Journal Article
• Language: English
• Published: Germany Elsevier GmbH 2004; Urban & Fischer Verlag; Elsevier Science Ltd
• Subjects: activity; Animals; Antimalarials - administration & dosage; Antimalarials - pharmacology; Antimalarials - therapeutic use; antiplasmodial; Care and treatment; Chloroquine; Cote d'Ivoire; cryptolepine; Drug Resistance; Health aspects; Inhibitory Concentration 50; Malaria; Malaria, Falciparum - prevention & control; Malvaceae; Medicinal plants; Phytotherapy; Plant Extracts - administration & dosage; Plant Extracts - pharmacology; Plant Extracts - therapeutic use; Plasmodium falciparum - drug effects; Sida acuta; Cote d'Ivoire; France; Sida acuta; activity; cryptolepine; antiplasmodial
• ISSN: 0944-7113; 1618-095X
• DOI: 10.1078/0944711041495245

Sida acuta Burm. (Malvaceae) originating from Ivory Coast was selected after an ethnobotanical survey: traditional healers of malaria commonly used this plant for the treatment. Extracts were tested on two strains of Plasmodium falciparum: FcM29-Cameroon (chloroquine-resistant strain) and a Nigerian chloroquine-sensitive strain. Extracts were obtained by preparing decoction in water of the powdered plant, the technique used by most of the traditional healers. An ethanol extract was then made and tested. The IC 50 values obtained for these extracts ranged from 3.9 to –5.4 μg/ml. Purification of this active fraction led to the identification of cryptolepine as the active antiplasmodial constituent of the plant.