Photoactive and Luminescent Transition Metal Complexes as Anticancer Agents: A Guiding Light in the Search for New and Improved Cancer Treatments

• Published in: Biomedicines Vol. 10; no. 3; p. 578
• Main Authors: McGhie, Brondwyn S, Aldrich-Wright, Janice R
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01.03.2022; MDPI
• Subjects: Antitumor agents; Apoptosis; cancer; Cancer therapies; chemotherapeutics; Chemotherapy; Cytotoxicity; iridium; Ligands; Light; Localization; luminescent; metal; Mitochondria; Optics; Organic compounds; Pharmacokinetics; Photodynamic therapy; Review; ruthenium; Transition metals; Viscosity; iridium; ruthenium; platinum; rhenium; photodynamic therapy; metal; osmium; cancer; luminescent; photoactivated chemotherapy; chemotherapeutics
• ISSN: 2227-9059; 2227-9059
• DOI: 10.3390/biomedicines10030578

Cancer continues to be responsible for the deaths of more than 9 million people worldwide each year. Current treatment options are diverse, but low success rates, particularly for those with late-stage cancers, continue to be a problem for clinicians and their patients. The effort by researchers globally to find alternative treatment options is ongoing. In the present study, we focused on innovations in inorganic anticancer therapies, specifically those with photoactive and luminescent properties. Transition metals offer distinct advantages compared to wholly organic compounds in both chemotherapeutics and luminescence properties. Here we report on the characteristics that result from discrete structural changes that have been expertly used to fine-tune their properties, and how diverse inherent luminescent properties have been widely employed to monitor cellular localization to photodynamic therapy.