profusion of upstream open reading frame mechanisms in polyamine-responsive translational regulation

In many eukaryotic mRNAs one or more short 'upstream' open reading frames, uORFs, precede the initiator of the main coding sequence. Upstream ORFs are functionally diverse as illustrated by their variety of features in polyamine pathway biosynthetic mRNAs. Their propensity to act as sensor...

Full description

Saved in:
Bibliographic Details
Published inNucleic acids research Vol. 38; no. 2; pp. 353 - 359
Main Authors Ivanov, Ivaylo P, Atkins, John F, Michael, Antony J
Format Journal Article
LanguageEnglish
Published England Oxford University Press 01.01.2010
Subjects
Acetyltransferases - genetics
Acetyltransferases - metabolism
Adenosylmethionine Decarboxylase - genetics
Adenosylmethionine Decarboxylase - metabolism
Animals
Carrier Proteins - genetics
Carrier Proteins - metabolism
Frameshifting, Ribosomal
Gene Expression Regulation
Open Reading Frames
Polyamines - metabolism
Protein Biosynthesis
Proteins - genetics
Proteins - metabolism
Spermine Synthase - genetics
Spermine Synthase - metabolism
Survey and Summary
Online AccessGet full text

Cover

More Information
Summary:In many eukaryotic mRNAs one or more short 'upstream' open reading frames, uORFs, precede the initiator of the main coding sequence. Upstream ORFs are functionally diverse as illustrated by their variety of features in polyamine pathway biosynthetic mRNAs. Their propensity to act as sensors for regulatory circuits and to amplify the signals likely explains their occurrence in most polyamine pathway mRNAs. The uORF-mediated polyamine responsive autoregulatory circuits found in polyamine pathway mRNAs exemplify the translationally regulated dynamic interface between components of the proteome and metabolism.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ObjectType-Article-1
ObjectType-Feature-2
ISSN:0305-1048
1362-4962
DOI:10.1093/nar/gkp1037