Molecular Imaging for Efficacy of Pharmacologic Intervention in Myocardial Remodeling

• Published in: JACC. Cardiovascular imaging Vol. 2; no. 2; pp. 187 - 198
• Main Authors: van den Borne, Susanne W.M., MD, Isobe, Satoshi, MD, PhD, Zandbergen, H. Reinier, MD, Li, Peng, MD, PhD, Petrov, Artiom, PhD, Wong, Nathan D., PhD, FACC, Fujimoto, Shinichiro, MD, PhD, Fujimoto, Ai, MD, PhD, Lovhaug, Dagfinn, PhD, Smits, Jos F.M., PhD, Daemen, Mat J.A.P., MD, PhD, Blankesteijn, W. Matthijs, PhD, Reutelingsperger, Chris, PhD, Zannad, Faiez, MD, PhD, FACC, Narula, Navneet, MD, Vannan, Mani A., MD, FACC, Pitt, Bertram, MD, FACC, Hofstra, Leonard, MD, PhD, Narula, Jagat, MD, PhD, FACC
• Format: Journal Article
• Language: English
• Published: United States 01.02.2009
• Subjects: Angiotensin II Type 1 Receptor Blockers - pharmacology; Angiotensin-Converting Enzyme Inhibitors - pharmacology; Animals; Captopril - pharmacology; Carbocyanines; Cardiovascular; Cardiovascular Agents - pharmacology; Disease Models, Animal; Drug Therapy, Combination; Echocardiography; Fibrillar Collagens - metabolism; Fibroblasts - diagnostic imaging; Fibroblasts - drug effects; Fibrosis; Losartan - pharmacology; Mice; Mineralocorticoid Receptor Antagonists - pharmacology; Myocardial Infarction - diagnostic imaging; Myocardial Infarction - drug therapy; Myocardial Infarction - physiopathology; Myocardium - metabolism; Myocardium - pathology; Oligopeptides; Predictive Value of Tests; Spironolactone - pharmacology; Technetium; Tomography, Emission-Computed, Single-Photon; Ventricular Function, Left - drug effects; Ventricular Remodeling - drug effects; remodeling; C; myocardial infarction; CRIP; Cy5.5-RGD imaging peptide; Arg-Gly-Asp; angiotensin receptor blocker; LV; alpha smooth muscle actin; angiotensin receptors; L; spironolactone; selective aldosterone receptor antagonist; S; technetium-99m; ASMA; left ventricular; SARA; losartan; MI; angiotensin-converting enzyme; heart failure; 99mTc; collagen; ACE-I; RGD; ARB; radionuclide imaging; angiotensin-converting enzyme inhibitor; captopril; scrambled Cy5.5-RGD imaging peptide; mineralocorticoids; sCRIP
• ISSN: 1936-878X; 1876-7591
• DOI: 10.1016/j.jcmg.2008.11.011

Molecular Imaging to Demonstrate Efficacy of Pharmacological Intervention in Myocardial Remodeling Susanne W. M. van den Borne, Satoshi Isobe, H. Reinier Zandbergen, Peng Li, Artiom Petrov, Nathan D. Wong, Shinichiro Fujimoto, Ai Fujimoto, Dagfinn Lovhaug, Jos F. M. Smits, Mat J. A. P. Daemen, W. Matthijs Blankesteijn, Chris Reutelingsperger, Faiez Zannad, Navneet Narula, Mani A. Vannan, Bertram Pitt, Leonard Hofstra, Jagat Narula Employing technetium-99m-labeled Cy5.5 RGD imaging peptide (99m Tc-CRIP) for molecular imaging, the authors examined interstitial alterations during post-myocardial infarction (MI) remodeling and assessed the efficacy of antiangiotensin and antimineralocorticoid intervention, alone and in combination.99m Tc-CRIP uptake decreased significantly in animals that were treated with 1 neurohumoral antagonist; 2 or 3 agents demonstrated further reduction in the tracer uptake. The extent of uptake correlated with echocardiographic parameters of ventricular remodeling and histologically-verified deposition of thin collagen fibers. Radiolabeled99m Tc-CRIP allows evaluation of the efficacy of neurohumoral antagonists post-MI by monitoring interstitial alterations and collagen deposition and confirms the superiority of combination therapy.