Cocaine-associated agitated delirium and the neuroleptic malignant syndrome

The incidence of this previously rare disorder, cocaine-associated agitated delirium, appears to have increased drastically within the last 18 months. The underlying neurochemical abnormalities have recently been characterized, but most clinicians have had little experience with management of agitat...

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Bibliographic Details
Published inAmerican Journal of Emergency Medicine Vol. 14; no. 4; pp. 425 - 428
Main Authors Wetli, Charles V, Mash, Deborah, Karch, Steven B
Format Book Review Journal Article
LanguageEnglish
Published Philadelphia, PA Elsevier Inc 01.07.1996
Elsevier
Subjects
Agitated delirium
Akathisia, Drug-Induced - etiology
Biological and medical sciences
Brain - drug effects
Brain - metabolism
cocaine
Cocaine - adverse effects
Delirium - chemically induced
Delirium - diagnosis
dopamine receptors
Drug addictions
hogtied
Humans
Medical sciences
Neuroleptic Malignant Syndrome - etiology
positional asphyxia
Substance-Related Disorders
Toxicology
dopamine receptors
Agitated delirium
cocaine
positional asphyxia
hogtied
Delirium
Human
Agitation
Chemotherapy
Neuroleptic
Pathogenesis
Animal
Cocaine
Psychopathology
Review
Differential diagnostic
Malignant syndrome
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Summary:The incidence of this previously rare disorder, cocaine-associated agitated delirium, appears to have increased drastically within the last 18 months. The underlying neurochemical abnormalities have recently been characterized, but most clinicians have had little experience with management of agitated delirium. The basic clinical and pathological features of this disorder are reviewed, and common pitfalls in diagnosis and management that frequently lead to needless but very expensive litigation are discussed.
ISSN:0735-6757
1532-8171
DOI:10.1016/S0735-6757(96)90066-2