Mutagenic Activity of Acrylamide in the Rat Thyroid Cells under Conditions of a Subacute Experiment

Experimental mutagenic effect of acrylamide on thyroid gland cells was studied by an extended micronucleus test. Acrylamide in doses corresponding to 0.004-0.1 LD 50 increased the incidence of thyroid follicular cells (A-cells) with micronuclei and other karyological parameters in exposed rats after...

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Published inBulletin of experimental biology and medicine Vol. 152; no. 2; pp. 275 - 277
Main Authors Altaeva, A. A., Sycheva, L. P., Belyaeva, N. N.
Format Journal Article
LanguageEnglish
Published Boston Springer US 01.12.2011
Springer
Springer Nature B.V
Subjects
Acrylamide - toxicity
Amides
Animal experimentation
Animals
Biomedical and Life Sciences
Biomedicine
Cell Biology
Internal Medicine
Laboratory Medicine
Male
Micronuclei, Chromosome-Defective
Mutagens - toxicity
Pathology
Rats
Rats, Wistar
Thyroid gland
Thyroid Gland - drug effects
thyroid gland
acrylamide
micronuclei
binuclear cells
cytogenetic disorders
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Summary:Experimental mutagenic effect of acrylamide on thyroid gland cells was studied by an extended micronucleus test. Acrylamide in doses corresponding to 0.004-0.1 LD 50 increased the incidence of thyroid follicular cells (A-cells) with micronuclei and other karyological parameters in exposed rats after hemithyroidectomy. This cytogenetic effect allows regarding acrylamide as a mutagen for the thyroid gland and as a carcinogen for this organ.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-011-1506-6