Ubiquitin signaling in immune responses

• Published in: Cell research Vol. 26; no. 4; pp. 457 - 483
• Main Authors: Hu, Hongbo, Sun, Shao-Cong
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.04.2016; Nature Publishing Group
• Subjects: 631/250/1933; 631/250/2152/569; 631/80/458/582; 631/80/86; Biomedical and Life Sciences; Cell Biology; Dendritic Cells - physiology; Immune Tolerance; Immunity; Inflammation - immunology; Life Sciences; Mitogen-Activated Protein Kinases - metabolism; Receptors, Cell Surface - metabolism; Review; Signal Transduction; T-Lymphocytes - immunology; Ubiquitin - metabolism; Ubiquitination; 信号转导; 信号通路; 免疫功能; 免疫反应; 免疫应答; 树突状细胞; 泛素化; 泛素连接酶; NF-κB; immune tolerance; innate immunity; T cell activation; autoimmunity; TRAF; ubiquitination; Peli1; adaptive immunity
• ISSN: 1001-0602; 1748-7838; 1748-7838
• DOI: 10.1038/cr.2016.40

Ubiquitination has emerged as a crucial mechanism that regulates signal transduction in diverse biological pro- cesses, including different aspects of immune functions. Ubiquitination regulates pattern-recognition receptor sig- naling that mediates both innate immune responses and dendritic cell maturation required for initiation of adaptive immune responses. Ubiquitination also regulates the development, activation, and differentiation of T cells, thereby maintaining efficient adaptive immune responses to pathogens and immunological tolerance to self-tissues. Like phosphorylation, ubiquitination is a reversible reaction tightly controlled by the opposing actions of ubiquitin ligases and deubiquitinases. Deregulated ubiquitination events are associated with immunological disorders, including auto- immune and inflammatory diseases.