Inhibited drinking and pica in rats following 2-deoxy-D-glucose

• Published in: Physiology & behavior Vol. 39; no. 6; p. 745
• Main Authors: Watson, P.J, Hawkins, C, McKinney, J, Beatey, S, Bartles, R.R, Rhea, K
• Format: Journal Article
• Language: English
• Published: United States 1987
• Subjects: Animals; Citrates; Citric Acid; COMPORTAMIENTO INGESTION LIQUIDOS; Deoxy Sugars - pharmacology; Deoxyglucose - pharmacology; DIGESTIVE DISORDERS; Drinking - drug effects; DRINKING HABITS; Food Deprivation; GLUCOSA; GLUCOSE; HABITUDE DE BOISSON; Kaolin; Male; Pica - chemically induced; Quinine; RAT; RATA; RATS; TRASTORNOS DIGESTIVOS; TROUBLE DIGESTIF; Water Deprivation
• ISSN: 0031-9384; 1873-507X
• DOI: 10.1016/0031-9384(87)90260-5

A sequence of studies sought to determine if 2-deoxy-D-glucose (2DG) produces malaise as a side effect. Drug treatment at dosages at least as low as 250 mg/kg triggered an immediate inhibition of fluid intake. In nondeprived animals, 750 mg/kg but not lower dosages of 2DG evoked a delayed but statistically significant level of pica as measured by kaolin consumption. Twenty-four hour food deprivation failed to produce pica, and previous claims that kaolin intake is a specific index of gastrointestinal distress therefore received additional support. Thirsty rats injected with 750 mg/kg 2DG displayed a delayed pattern of pica largely similar to that previously observed with undeprived subjects; although, under optimal circumstances, significant increases in kaolin consumption may be evident as soon as one hour post-injection. In general, these data indicated that malaise may be an important influence of 2DG; but dosage and time course parameters associated with post-drug reductions in drinking suggested that a separable consummatory inhibition effect may also occur.