Human Milk and Allergic Diseases: An Unsolved Puzzle

There is conflicting evidence on the protective role of breastfeeding in relation to the development of allergic sensitisation and allergic disease. Studies vary in methodology and definition of outcomes, which lead to considerable heterogeneity. Human milk composition varies both within and between...

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Published inNutrients Vol. 9; no. 8; p. 894
Main Authors Munblit, Daniel, Peroni, Diego, Boix-Amorós, Alba, Hsu, Peter, Land, Belinda, Gay, Melvin, Kolotilina, Anastasia, Skevaki, Chrysanthi, Boyle, Robert, Collado, Maria, Garssen, Johan, Geddes, Donna, Nanan, Ralph, Slupsky, Carolyn, Wegienka, Ganesa, Kozyrskyj, Anita, Warner, John
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 17.08.2017
MDPI
Subjects
Baby foods
Breast Feeding
breast milk
Breastfeeding & lactation
Humans
hypersensitivity
Hypersensitivity - immunology
Hypersensitivity - prevention & control
Meta-Analysis as Topic
metabolites
Microbiota
Micronutrients - analysis
Milk
milk composition
Milk, Human - chemistry
Milk, Human - microbiology
nutrients
Observational Studies as Topic
oligosaccharides
Oligosaccharides - analysis
protective effect
Randomized Controlled Trials as Topic
Review
vitamins
thymus
oligosaccharides
allergy
cytokines
human milk
breastfeeding
microbiome
allergic diseases
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Summary:There is conflicting evidence on the protective role of breastfeeding in relation to the development of allergic sensitisation and allergic disease. Studies vary in methodology and definition of outcomes, which lead to considerable heterogeneity. Human milk composition varies both within and between individuals, which may partially explain conflicting data. It is known that human milk composition is very complex and contains variable levels of immune active molecules, oligosaccharides, metabolites, vitamins and other nutrients and microbial content. Existing evidence suggests that modulation of human breast milk composition has potential for preventing allergic diseases in early life. In this review, we discuss associations between breastfeeding/human milk composition and allergy development.
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All authors contributed equally to this work.
ISSN:2072-6643
2072-6643
DOI:10.3390/nu9080894