The small peptide world in long noncoding RNAs

Abstract Long noncoding RNAs (lncRNAs) are a group of transcripts that are longer than 200 nucleotides (nt) without coding potential. Over the past decade, tens of thousands of novel lncRNAs have been annotated in animal and plant genomes because of advanced high-throughput RNA sequencing technologi...

Full description

Saved in:
Bibliographic Details
Published inBriefings in bioinformatics Vol. 20; no. 5; pp. 1853 - 1864
Main Authors Choi, Seo-Won, Kim, Hyun-Woo, Nam, Jin-Wu
Format Journal Article
LanguageEnglish
Published England Oxford University Press 27.09.2019
Oxford Publishing Limited (England)
Subjects
Gene sequencing
Genomes
Non-coding RNA
Nucleotides
Peptides
Review
long noncoding RNA (lncRNA)
small peptide
small ORF
coding-potential prediction
Online AccessGet full text

Cover

More Information
Summary:Abstract Long noncoding RNAs (lncRNAs) are a group of transcripts that are longer than 200 nucleotides (nt) without coding potential. Over the past decade, tens of thousands of novel lncRNAs have been annotated in animal and plant genomes because of advanced high-throughput RNA sequencing technologies and with the aid of coding transcript classifiers. Further, a considerable number of reports have revealed the existence of stable, functional small peptides (also known as micropeptides), translated from lncRNAs. In this review, we discuss the methods of lncRNA classification, the investigations regarding their coding potential and the functional significance of the peptides they encode.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
ObjectType-Literature Review-3
ObjectType-Review-3
content type line 23
ISSN:1467-5463
1477-4054
1477-4054
DOI:10.1093/bib/bby055