Death following intentional ingestion of e-liquid

Context: Electronic cigarette (e-cigarette) use is growing within the United States, resulting in both intentional and unintentional exposures to concentrated liquid nicotine or "e-liquid." Nicotine has been culpable for severe poisoning and deaths in the past. However, sources of nicotine...

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Published inClinical toxicology (Philadelphia, Pa.) Vol. 53; no. 9; pp. 914 - 916
Main Authors Chen, Betty C., Bright, Steven B., Trivedi, Amit Raj, Valento, Matthew
Format Journal Article
LanguageEnglish
Published England Informa Healthcare 21.10.2015
Subjects
Biomarkers - blood
Cotinine - blood
E-cigarettes
E-liquid
Electronic Nicotine Delivery Systems - adverse effects
Fatal Outcome
Female
Heart Arrest - blood
Heart Arrest - chemically induced
Heart Arrest - diagnosis
Heart Arrest - physiopathology
Heart Arrest - therapy
Hemodynamics - drug effects
Humans
Liquid nicotine
Nicotine - blood
Nicotine - poisoning
Nicotinic Agonists - blood
Nicotinic Agonists - poisoning
Poisoning - diagnosis
Poisoning - physiopathology
Poisoning - therapy
Public health
Risk Factors
Suicide
Treatment Outcome
Young Adult
E-cigarettes
Liquid nicotine
E-liquid
Public health
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Summary:Context: Electronic cigarette (e-cigarette) use is growing within the United States, resulting in both intentional and unintentional exposures to concentrated liquid nicotine or "e-liquid." Nicotine has been culpable for severe poisoning and deaths in the past. However, sources of nicotine have traditionally been from cigarettes, cigars, or pesticides. Fatalities due to liquid nicotine are rare, and fatalities following ingestion of e-liquid are even scarcer. Case: We present a case of a 24-year-old woman who intentionally ingested up to 3000 mg of liquid nicotine intended for e-cigarette use. She was found in pulseless electrical activity and had return of spontaneous circulation (ROSC) after undergoing approximately 10 min of cardiopulmonary resuscitation with a blood pressure of 74/53 mmHg and a pulse rate of 106 beats/min. Despite aggressive supportive care, she ultimately died after she was found to have multiple acute infarcts, consistent with severe anoxic brain injury, on magnetic resonance imaging. The patient's toxicologic testing, obtained shortly after ROSC, was notable for plasma nicotine and cotinine levels each >1000 ng/mL. Discussion: This fatality highlights the potential toxicity associated with suicidal ingestion of liquid nicotine.
ISSN:1556-3650
1556-9519
DOI:10.3109/15563650.2015.1090579