Identification of new components of the basal pole of Toxoplasma gondii provides novel insights into its molecular organization and functions

• Published in: Frontiers in cellular and infection microbiology Vol. 12; p. 1010038
• Main Authors: Roumégous, Chloé, Abou Hammoud, Aya, Fuster, Damien, Dupuy, Jean-William, Blancard, Corinne, Salin, Bénédicte, Robinson, Derrick R., Renesto, Patricia, Tardieux, Isabelle, Frénal, Karine
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers 13.10.2022; Frontiers Media S.A
• Subjects: Apicomplexa; basal complex; Cell Division; Cellular and Infection Microbiology; constriction; cytoskeleton; Cytoskeleton - metabolism; Humans; Life Sciences; Microbiology and Parasitology; myosin heavy chain (MHC); Parasitology; Protozoan Proteins - genetics; Protozoan Proteins - metabolism; Toxoplasma - metabolism; Toxoplasma gondii; Toxoplasmosis - parasitology; constriction; Apicomplexa; expansion microscopy; Toxoplasma gondii; cytoskeleton; myosin heavy chain (MHC); basal complex; cell-cell communication; Myosin

The Toxoplasma gondii tachyzoite is a singled-cell obligate intracellular parasite responsible for the acute phase of toxoplasmosis. This polarized cell exhibits an apical complex, a hallmark of the phylum Apicomplexa, essential for motility, invasion, and egress from the host cell. Located on the o...