IT-143-A and B, novel piericidin-group antibiotics produced by Streptomyces sp

• Published in: Journal of antibiotics Vol. 49; no. 10; pp. 1052 - 1055
• Main Authors: Urakawa, A, Sasaki, T, Yoshida, K, Otani, T, Lei, Y, Yun, W
• Format: Journal Article
• Language: English
• Published: TOKYO Japan Antibiotics Research Assoc 01.10.1996; Japan Antibiotics Research Association
• Subjects: Anti-Bacterial Agents - chemistry; Anti-Bacterial Agents - isolation & purification; Antibiotics. Antiinfectious agents. Antiparasitic agents; Biological and medical sciences; Biotechnology & Applied Microbiology; Chromatography, High Pressure Liquid; Immunology; Life Sciences & Biomedicine; Magnetic Resonance Spectroscopy; Medical sciences; Microbial Sensitivity Tests; Microbiology; Miscellaneous. Antibiotics with multiple activities; Pharmacology & Pharmacy; Pharmacology. Drug treatments; Pyridines - chemistry; Pyridines - isolation & purification; Science & Technology; Spectrophotometry, Ultraviolet; Streptomyces; Streptomyces - classification; Streptomyces - metabolism; TURNOVER; GROWTH-FACTOR; TRANSFORMED CELLS; PACTUM; Streptomycetaceae; Molecular structure; Taxonomy; Streptomyces; NMR spectrometry; In vitro; Micrococcus luteus; Biological activity; Actinomycetales; Fungi; Antibiotic; Microbial origin; Structure activity relation; Established cell line; Bacteria; Micrococcales; Isolation; Actinomycetes; Micrococcaceae; Fungi Imperfecti; Aspergillus fumigatus; Comparative study; Thallophyta
• ISSN: 0021-8820; 1881-1469
• DOI: 10.7164/antibiotics.49.1052

During the course of our screening program for new potent cytotoxic compounds, we found four piericidin group antibiotics, designated as IT-143-A, B, C, and D, in the culture mycelia of Streptomyces sp. IT-143. Of these isolated antibiotics, IT-143-A (I) and B (II) were shown to be new piericidin antibiotics, whereas IT-143-C (III) and D (IV) were identical to the known antibiotics, piericidin A sub(2) and A sub(1), respectively. In this communication, we describe the taxonomical characteristics of the producing strain and the fermentation procedure as well as the isolation, structure, and biological properties of these two new antibiotics in comparison with those of III (piericidin A sub(2)) and IV (piericidin A sub(1)).