The immunosuppressant FK-506 specifically inhibits mitogen-induced activation of the interleukin-2 promoter and the isolated enhancer elements NFIL-2A and NF-AT1

• Published in: Molecular and Cellular Biology Vol. 11; no. 8; pp. 4074 - 4087
• Main Authors: BANERJI, S. S, PARSONS, J. N, TOCCI, M. J
• Format: Journal Article
• Language: English
• Published: Washington, DC American Society for Microbiology 01.08.1991
• Subjects: Anti-Bacterial Agents - pharmacology; Base Sequence; Biological and medical sciences; Cell Line; Cell Nucleus - physiology; Chloramphenicol O-Acetyltransferase - genetics; Chloramphenicol O-Acetyltransferase - metabolism; Concanavalin A - pharmacology; DNA-Binding Proteins - metabolism; Enhancer Elements, Genetic - drug effects; Fundamental and applied biological sciences. Psychology; Gene Expression Regulation - drug effects; Humans; Immunosuppressive Agents - pharmacology; Interleukin-2 - genetics; Ionomycin - pharmacology; Kinetics; Molecular and cellular biology; Molecular genetics; Molecular Sequence Data; NF-kappa B - genetics; Oligonucleotide Probes; Promoter Regions, Genetic - drug effects; Regulatory Sequences, Nucleic Acid - drug effects; Retroviridae - drug effects; Retroviridae - genetics; Tacrolimus; TATA Box - drug effects; Tetradecanoylphorbol Acetate - pharmacology; Transcription. Transcription factor. Splicing. Rna processing; Human; Cell line; Transfection; Transcription; Interleukin 2; Transcription promoter; Leukemia; Cytokine; T-Lymphocyte; Immunosuppressive agent; Inhibition; Macrolide
• ISSN: 0270-7306; 1098-5549
• DOI: 10.1128/MCB.11.8.4074

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