PharmGKB: the Pharmacogenetics Knowledge Base

• Published in: Nucleic acids research Vol. 30; no. 1; pp. 163 - 165
• Main Authors: Hewett, Micheal, Oliver, Diane E, Rubin, Daniel L, Easton, Katrina L, Stuart, Joshua M, Altman, Russ B, Klein, Teri E
• Format: Journal Article
• Language: English
• Published: England Oxford Publishing Limited (England) 01.01.2002; Oxford University Press
• Subjects: Biotransformation - genetics; Database Management Systems; Databases, Factual; Drug Therapy; Enzymes - metabolism; Genetic Variation; Genome, Human; Humans; Information Storage and Retrieval; Internet; Pharmaceutical Preparations - metabolism; Pharmacogenetics; Phenotype; Polymorphism, Single Nucleotide; User-Computer Interface
• ISSN: 1362-4962; 0305-1048; 1362-4962
• DOI: 10.1093/nar/30.1.163

The Pharmacogenetics Knowledge Base (PharmGKB; http://www.pharmgkb.org/) contains genomic, phenotype and clinical information collected from ongoing pharmacogenetic studies. Tools to browse, query, download, submit, edit and process the information are available to registered research network members. A subset of the tools is publicly available. PharmGKB currently contains over 150 genes under study, 14 Coriell populations and a large ontology of pharmacogenetics concepts. The pharmacogenetic concepts and the experimental data are interconnected by a set of relations to form a knowledge base of information for pharmacogenetic researchers. The information in PharmGKB, and its associated tools for processing that information, are tailored for leading-edge pharmacogenetics research. The PharmGKB project was initiated in April 2000 and the first version of the knowledge base went online in February 2001.