Current status of publicly available sarcoma cell lines for use in proteomic studies

Cell lines are valuable resources for proteomic studies and can be used as tools to verify the significance of proteomic findings. Here, the authors overview the current status of the publicly available sarcoma cell lines. The authors surveyed seven major cell banks and found that the diversity obse...

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Bibliographic Details
Published inExpert review of proteomics Vol. 13; no. 2; p. 227
Main Authors Pan, Xiaoqing, Yoshida, Akihiko, Kawai, Akira, Kondo, Tadashi
Format Journal Article
LanguageEnglish
Published England 01.02.2016
Subjects
Cell Line, Tumor
Humans
Proteomics
Sarcoma - diagnosis
Sarcoma - metabolism
Sarcoma - pathology
cell bank
therapeutic target
Sarcoma
proteomics
biomarker
cell line
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Summary:Cell lines are valuable resources for proteomic studies and can be used as tools to verify the significance of proteomic findings. Here, the authors overview the current status of the publicly available sarcoma cell lines. The authors surveyed seven major cell banks and found that the diversity observed in the sarcoma cell banks was largely insufficient; sarcoma cell lines are available for only a limited histological subtype. They also observed a number of issues with the pathological diagnosis of the cell lines, limitations in their behavioral diversity, and various unmet needs. Well characterized cell lines with accurate diagnosis based on modern diagnosis criteria should be available from public cell banks. The authors conclude that additional cell lines, along with detailed genetic and pathological analyses, should be prepared and deposited in order to promote sarcoma-specific proteomic research. The authors focused on sarcoma cell lines, but their discussion can be applied to the other cancers.
ISSN:1744-8387
DOI:10.1586/14789450.2016.1132166