Altered Autonomic Functions and Gut Microbiome in Individuals with Autism Spectrum Disorder (ASD): Implications for Assisting ASD Screening and Diagnosis

• Published in: Journal of autism and developmental disorders Vol. 51; no. 1; pp. 144 - 157
• Main Authors: Kong, Xuejun, Liu, Jun, Liu, Kevin, Koh, Madelyn, Tian, Ruiyi, Hobbie, Clara, Fong, Michelle, Chen, Qiuyi, Zhao, Minxuan, Budjan, Christoph, Kong, Jian
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.01.2021; Springer; Springer Nature B.V
• Subjects: Adolescent; Adult; Analysis; Anatomy; Autism; Autism Spectrum Disorder - diagnosis; Autism Spectrum Disorder - physiopathology; Autism Spectrum Disorder - psychology; Autism Spectrum Disorders; Autonomic nervous system; Autonomic Nervous System Diseases - diagnosis; Autonomic Nervous System Diseases - physiopathology; Autonomic Nervous System Diseases - psychology; Behavioral Science and Psychology; Biological markers; Brain; Brain - physiopathology; Central nervous system; Child; Child and School Psychology; Clinical Diagnosis; Clinical standards; Comorbidity; Developmental disabilities; Diagnosis; Diagnostic tests; Digestive system; Enteric nervous system; Female; Gastrointestinal diseases; Gastrointestinal Diseases - diagnosis; Gastrointestinal Diseases - physiopathology; Gastrointestinal Diseases - psychology; Gastrointestinal Microbiome - physiology; Gastrointestinal tract; Gut microbiota; Gut-brain axis; Human Body; Humans; Immune system; Intestinal microflora; Male; Mass Screening - methods; Measurement; Medical diagnosis; Medical examination; Medical screening; Microbiomes; Microbiota; Microbiota (Symbiotic organisms); Mucosal immunity; Nervous system; Nervous system, Autonomic; Neurological Impairments; Neurological Organization; Neurosciences; Non-invasive; Original Paper; Pediatrics; Pervasive Developmental Disorders; Physiological aspects; Physiology; Prediction; Psychological assessment; Psychological Testing; Psychological Tests; Psychology; Public Health; Research subjects; Screening Tests; Vagus nerve; Young Adult; United States; Autonomic dysfunction; Autism spectrum disorders (ASD); Biomarker; Gut-brain-axis; Gut microbiome

Autism spectrum disorder (ASD) is a complex neurological and developmental disorder, and a growing body of literature suggests the presence of autonomic nervous system (ANS) dysfunction in individuals with ASD. ANS is part of the “gut brain axis”, which consists of an intricate interplay between the...