Physical and psychological stress along with candle fumes induced-cardiopulmonary injury mimicking restaurant kitchen workers

• Published in: Current research in toxicology Vol. 2; pp. 246 - 253
• Main Authors: Chandrasekaran, Victor Raj Mohan, Periasamy, Srinivasan, Chien, Se-Ping, Tseng, Chu-Han, Tsai, Perng-Jy, Liu, Ming-Yie
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 01.01.2021; Elsevier
• Subjects: Cardiopulmonary injury; Occupational restaurant stress; Scented candle fumes; Social Disruption stress (SDR); Scented candle fumes; Cardiopulmonary injury; Social Disruption stress (SDR); Occupational restaurant stress
• ISSN: 2666-027X; 2666-027X
• DOI: 10.1016/j.crtox.2021.07.001

[Display omitted] •Exposure to burning scented candles failed to reduce serum corticosterone levels.•Social disruption stress and scented candle fumes synergistically increase lung and heart inflammation.•Social disruption stress and scented candle fumes-induced cardiopulmonary injury can be extrapolated to restaurant kitchen workers. Restaurant kitchens are work areas where involve strict and hierarchal environments that promote opportunity for bullying and workplace aggression and violence. These physical and psychological stress and fumes ultimately trigger severe occupational stress by disrupting the body's homeostasis that might induce cardiopulmonary injury. The study aimed to investigate the physical and psychological stress and candle fumes on cardiopulmonary injury in an animal model mimicking a restaurant kitchen worker. Social disruption stress (SDR) mice were exposed to scented candle fumes (4.5 h/d, 5 d/wk) in an exposure chamber for 8 weeks. Exposure to burning scented candles failed to reduce serum corticosterone level and increased proinflammatory cytokines levels and NF-ƙB activity in the lung. In addition, burning scented candle fumes synergistically increased SDR-induced serum LDH, CPK, CKMB levels, proinflammatory cytokines production as well as NF-ƙB activation in the lung and heart. Further, cardiac HIF-1α and BNP levels were also increased. We conclude that the physical and psychological stress along with candle fumes might induce cardiopulmonary injury in mice. These results could be extrapolated to restaurant kitchen workers.