B7H4, HSP27 and DJ-1 molecular markers as prognostic factors in pancreatic cancer

• Published in: Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] Vol. 13; no. 6; pp. 564 - 569
• Main Authors: Tsiaousidou, A, Lambropoulou, M, Chatzitheoklitos, E, Tripsianis, G, Tsompanidou, C, Simopoulos, C, Tsaroucha, A.K
• Format: Journal Article
• Language: English
• Published: Switzerland Elsevier B.V 01.11.2013; Elsevier Limited
• Subjects: Adenocarcinoma - diagnosis; Adenocarcinoma - drug therapy; Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic - therapeutic use; Biomarkers; Biomarkers, Tumor - analysis; Breast cancer; Chemotherapy; Chemotherapy resistance; Deoxycytidine - analogs & derivatives; Deoxycytidine - therapeutic use; Drug Resistance, Neoplasm - genetics; Endocrinology & Metabolism; Fatalities; Female; Gastroenterology and Hepatology; HSP27 Heat-Shock Proteins - analysis; Humans; Immunohistochemistry; Intracellular Signaling Peptides and Proteins - analysis; Lung cancer; Male; Middle Aged; Neoplasm Staging; Oncogene Proteins - analysis; Pancreas; Pancreatic cancer; Pancreatic Neoplasms - diagnosis; Pancreatic Neoplasms - drug therapy; Prognosis; Protein Deglycase DJ-1; Survival Analysis; V-Set Domain-Containing T-Cell Activation Inhibitor 1 - analysis; Immunohistochemistry; Biomarkers; Chemotherapy resistance; Pancreatic cancer
• ISSN: 1424-3903; 1424-3911
• DOI: 10.1016/j.pan.2013.10.005

Abstract Objectives Pancreatic cancer (PC) is one of the most lethal tumors of the gastrointestinal tract. The ability to predict which patients would benefit most from surgical intervention and chemotherapy would be a great clinical tool. A large number of potential markers have been identified lately in pancreatic cancer and their clinical utilities as prognostic tools are under investigation. Methods We recruited 41 patients who had undergone radical surgical resection for PC between 2003 and 2010. To investigate the prognostic factors, we evaluated 3 possible markers: B7H4, HSP27 and DJ-1 protein expressions in the tissue specimens of these 41 patients by immunohistochemistry and analyzed the clinical and pathological features of these specimens. Results The expression of the three antigens was independently associated with a negative impact of chemotherapy with gemcitabine on patient's survival. Moreover, patients who overexpressed B7H4 had worse prognosis than the ones who did not. Conclusions B7H4, DJ-1 and HSP27 may be used in the future as prognostic markers that express resistance of pancreatic cancer patients to chemotherapy with gemcitabine.