Dose-response relationship between polycyclic aromatic hydrocarbon metabolites and risk of diabetes in the general Chinese population

• Published in: Environmental pollution (1987) Vol. 195; pp. 24 - 30
• Main Authors: Yang, Liangle, Zhou, Yun, Sun, Huizhen, Lai, Hanpeng, Liu, Chuanyao, Yan, Kai, Yuan, Jing, Wu, Tangchun, Chen, Weihong, Zhang, Xiaomin
• Format: Journal Article
• Language: English
• Published: Kidlington Elsevier 01.12.2014
• Subjects: Adult; Biochemistry; Biological and medical sciences; Chemical and industrial products toxicology. Toxic occupational diseases; China - epidemiology; Diabetes; Diabetes Mellitus - epidemiology; Diabetes. Impaired glucose tolerance; dose response; Dose-Response Relationship, Drug; Elevated; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; Environmental Exposure - analysis; Environmental Exposure - statistics & numerical data; environmental factors; Environmental Pollutants - metabolism; etiology; Etiopathogenesis. Screening. Investigations. Target tissue resistance; Female; females; Humans; Male; Mathematical models; Medical sciences; Metabolites; Pollution abatement; Polycyclic aromatic hydrocarbons; Polycyclic Aromatic Hydrocarbons - metabolism; questionnaires; Risk; Risk Factors; Toxicology; Various organic compounds; Asia; China; Endocrinopathy; Human; Hydrocarbon; Metabolite; Toxicity; Diabetes mellitus; Polycyclic aromatic compound; Dose activity relation; Persistent organic pollutant; Pollutant; Polycyclic aromatic hydrocarbons; Risk factor; Dose-response relationship; Diabetes; Degradation product; Public health; Organic compounds
• ISSN: 0269-7491; 1873-6424; 1873-6424
• DOI: 10.1016/j.envpol.2014.08.012

The incidence of diabetes is increasing rapidly in Chinese population, and it has been postulated that environmental factors may play a role in the etiology of diabetes. Therefore, we aimed to investigate the association between PAHs exposure and risk of diabetes in a community-based population of 2824 participants with completed questionnaires, measurements of biochemical indices, and urinary PAHs metabolites. We found that elevated urinary PAHs metabolites were associated, in a dose-dependent manner, with increased risk of diabetes. Particularly, these associations were more evident in subjects who were female, less than 55 years old, nonsmokers, and normal weight. In addition, there was a modest improvement in diabetes discrimination of prediction models when incorporating certain PAHs metabolites into conventional risk factors (CRF). Overall, our data suggested that there may be a dose-dependent relationship between PAHs metabolites and risk of diabetes among general Chinese population.