The first comprehensive study of praziquantel effects in vivo and in vitro on European liver fluke Opisthorchis felineus (Trematoda)

Highlights • Heterogeneity of worms following praziquantel (PZQ) treatment was observed. • PZQ reduced the rate of infection in hamsters only by 70–79%. • The IC50 for Opisthorchis felineus was 0.14 μg/mL. • The worm surface after 1 day of PZQ treatment became impervious to propidium iodide....

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Bibliographic Details
Published inInternational journal of antimicrobial agents Vol. 46; no. 1; pp. 94 - 100
Main Authors Pakharukova, Mariya Y, Shilov, Alexander G, Pirozhkova, Darya S, Katokhin, Alexey V, Mordvinov, Viatcheslav A
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 01.07.2015
Subjects
Animals
Anthelmintics - administration & dosage
Anthelmintics - pharmacology
Disease Models, Animal
Histocytochemistry
Infectious Disease
Inhibitory Concentration 50
Locomotion - drug effects
Mesocricetus
Microscopy
Opisthorchiasis - drug therapy
Opisthorchiasis - parasitology
Opisthorchis - anatomy & histology
Opisthorchis - drug effects
Opisthorchis - physiology
Opisthorchis felineus
Praziquantel
Praziquantel - administration & dosage
Praziquantel - pharmacology
Surface damage Worm reduction
Treatment Outcome
Opisthorchis felineus
Praziquantel
Surface damage Worm reduction
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Summary:Highlights • Heterogeneity of worms following praziquantel (PZQ) treatment was observed. • PZQ reduced the rate of infection in hamsters only by 70–79%. • The IC50 for Opisthorchis felineus was 0.14 μg/mL. • The worm surface after 1 day of PZQ treatment became impervious to propidium iodide.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0924-8579
1872-7913
DOI:10.1016/j.ijantimicag.2015.02.012