Temporal trends of esophageal cancer during 1995-2004 in Nanao Island, an extremely high-risk area in China

• Published in: European journal of epidemiology Vol. 22; no. 1; pp. 43 - 48
• Main Authors: Su, Min, Liu, Min, Tian, Dong-Ping, Li, Xiao-Yun, Zhang, Guo-Hong, Yang, He-Lin, Fan, Xiaolong, Huang, Hai-Hua, Gao, Yu-Xia
• Format: Journal Article
• Language: English
• Published: Dordrecht Dordrecht : Kluwer Academic Publishers 2007; Springer; Springer Nature B.V
• Subjects: Age Distribution; Biological and medical sciences; Cancer; Cancer incidence; China - epidemiology; Colorectal cancer; Environmental Exposure; Environmental factors; Environmental health; Epidemiology; esophageal cancer; esophageal neoplasms; Esophageal Neoplasms - epidemiology; Esophageal Neoplasms - pathology; Esophagus; Family history; Female; Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi; Gastroenterology. Liver. Pancreas. Abdomen; General aspects; Genetic Predisposition to Disease; Genetics; Health Sciences; High-risk population; Humans; Hälsovetenskap; Incidence; Liver cancer; Lung cancer; Lung neoplasms; Male; Medical and Health Sciences; Medical sciences; Medicin och hälsovetenskap; Middle Aged; Miscellaneous; Native peoples; Neoplasm Metastasis; neoplasms; Neoplasms - epidemiology; Pancreatic cancer; Population genetics; Public Health, Global Health, Social Medicine and Epidemiology; Public health. Hygiene; Public health. Hygiene-occupational medicine; Registries; Risk factors; Sex Distribution; Stomach cancer; Tumors; Asia; China; ISEW, South China Sea; INW, Japan, Honshu, Ishikawa Prefect., Nanao; China, People's Rep; Human; High risk; Esophageal disease; Trend; Malignant tumor; Epidemiology; Esophagus cancer; 1995; High-risk population; 2004; Digestive diseases; Population; Public health; Esophageal cancer; Cancer
• ISSN: 0393-2990; 1573-7284; 1573-7284
• DOI: 10.1007/s10654-006-9086-x

The purpose of our study was to investigate the temporal malignant tumor incidence rates among the 70,000 residents at the relatively isolated Nanao Island in South China Sea. The data on all malignant tumor cases from Nanao Cancer Registry during 1995-2004 were coded, computerized, and analyzed using the software SPSS10.0. The tumor incident cases, crude incident rate, age-standardized incidence rate, their sex distribution and temporal trend were assessed. A total of 1450 new cancer cases (990 males and 460 females) were identified. The annual average age-standardized incidence rate (ASR) of malignant tumors was 208.18/100,000. The age-standardized incidence rate of the ten leading cancers in both sexes combined per 100,000 population were 74.47 for esophageal cancer (EC), 34.81 for cardiac cancer (CC), 25.66 for liver cancer, 26.01 for lung cancer, 18.52 for stomach cancer, 4.45 for nasopharyngeal cancer, 3.91 for breast cancer, 2.53 for colon/rectum cancer, 2.45 for bladder cancer and 1.92 for pancreatic cancer. These ten types of cancers make up to 93% of all cancer cases, with EC and CC being the most prevalent and making up 52% of the total cases. The incidence rates of esophagus, liver, lung, breast, nasopharyngeal, and colon/rectum cancers showed increasing trends during the period from 1995 to 2004 in Nanao Island. Astounding the EC ASR were 72-150/100,000 among male and 26-64/100,000 among female in Nanao Island during 1995-2004. The EC incidence rate in Nanao population is among the highest across the world, which suggests that there are potential genetic and/or environmental factors affecting this particular population.