Enhanced or Impaired Cognitive Function in Parkinson's Disease as a Function of Dopaminergic Medication and Task Demands
We investigated how dopamine (DA) systems contribute to cognitive performance in the domain of learning and attentional flexibility by examining effects of withdrawing DA-ergic medication in patients with Parkinson's disease (PD). Medication remediated impairments in switching between two tasks...
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Published in | Cerebral cortex (New York, N.Y. 1991) Vol. 11; no. 12; pp. 1136 - 1143 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
United States
Oxford University Press
01.12.2001
Oxford Publishing Limited (England) |
Subjects | |
Online Access | Get full text |
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Summary: | We investigated how dopamine (DA) systems contribute to cognitive performance in the domain of learning and attentional flexibility by examining effects of withdrawing DA-ergic medication in patients with Parkinson's disease (PD). Medication remediated impairments in switching between two tasks, thought to depend on circuitry connecting the dorsolateral prefrontal cortex and the posterior parietal cortex to the dorsal caudate nucleus, which is profoundly DA-depleted in PD. By contrast, the same medication impaired probabilistic reversal learning that implicates orbitofrontal cortex– ventral striatal circuitry, which is relatively spared of DA loss in PD. Hence, DA-ergic medication improves or impairs cognitive performance depending on the nature of the task and the basal level of DA function in underlying cortico-striatal circuitry. |
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Bibliography: | PII:1460-2199 local:0111136 Trevor W. Robbins, University of Cambridge, Department of Experimental Psychology, Downing Street, Cambridge CB2 3EB, UK. Email: twr2@cam.ac.uk. istex:E1D54CCFD780B33A1B2E93970B52A75EF88AE572 ark:/67375/HXZ-HTFZ6XQS-N ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 |
ISSN: | 1047-3211 1460-2199 1460-2199 |
DOI: | 10.1093/cercor/11.12.1136 |