Controllable delivery of hydrophilic and hydrophobic drugs from electrospun poly(lactic-co-glycolic acid)/mesoporous silica nanoparticles composite mats

• Published in: Journal of biomedical materials research. Part B, Applied biomaterials Vol. 100B; no. 8; pp. 2178 - 2186
• Main Authors: Song, Botao, Wu, Chengtie, Chang, Jiang
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.11.2012; Wiley-Blackwell
• Subjects: Biological and medical sciences; Delayed-Action Preparations; electrospinning; Fluorescein - chemistry; hydrophilic drug; Hydrophobic and Hydrophilic Interactions; hydrophobic drug; Lactic Acid - chemistry; Medical sciences; mesoporous silica nanoparticle; Nanoparticles - chemistry; Polyglycolic Acid - chemistry; Rhodamines - chemistry; Silicon Dioxide; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases; sustained release; Technology. Biomaterials. Equipments; Glycolic acid copolymer; Mat; Lactone copolymer; mesoporous silica nanoparticle; Controlled release form; Nanoparticle; hydrophilic drug; sustained release; Lactic acid copolymer; hydrophobic drug; Electrospinning; Silica; Composite material; Mesoporosity; Biomaterial; Biomedical engineering
• ISSN: 1552-4973; 1552-4981
• DOI: 10.1002/jbm.b.32785

Co‐delivery of several drugs has been regarded as an alternative strategy for achieving enhanced therapeutic effect. In this study, a co‐delivery system based on the electrospun poly(lactic‐co‐glycolic acid) (PLGA)/mesoporous silica nanoparticles (MSNs) composite mat was designed for the co‐encapsulation and prolonged release of one hydrophilic and one hydrophobic drug simultaneously. MSNs were chosen to load the hydrophobic model drug fluorescein (FLU) and hydrophilic model drug rhodamine B (RHB), respectively (named as RHB‐loaded MSNs and FLU‐loaded MSNs). Two kinds of drug‐loaded MSNs were incorporated into the polymer matrix to form a fibrous structure by blending electrospinning. The effect of the weight ratios for the two kinds of drug‐loaded MSNs and the initial PLGA concentrations on the drug release kinetics were systematically investigated. The results showed that both model drugs RHB and FLU maintained sustained delivery with controllable release kinetics during the releasing period, and the release kinetics was closely dependent on the loading ratios of two drug‐loaded MSNs and the initial PLGA concentrations in the composite mats. The results suggest that the co‐drug delivery system may be used for wound dressing that requires the combined therapy of several kinds of drugs. © 2012 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2012.