Hydrogen sulfide signaling in mitochondria and disease

Hydrogen sulfide can signal through 3 distinct mechanisms: ) reduction and/or direct binding of metalloprotein heme centers, ) serving as a potent antioxidant through reactive oxygen species/reactive nitrogen species scavenging, or ) post-translational modification of proteins by addition of a thiol...

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Bibliographic Details
Published inThe FASEB journal Vol. 33; no. 12; p. 13098
Main Authors Murphy, Brennah, Bhattacharya, Resham, Mukherjee, Priyabrata
Format Journal Article
LanguageEnglish
Published United States 01.12.2019
Subjects
Animals
Cystathionine gamma-Lyase - metabolism
Disease
Humans
Hydrogen Sulfide - metabolism
Mitochondria - metabolism
Signal Transduction
Sulfurtransferases - metabolism
H2S
persulfidation
apoptosis
metabolism
ROS
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Summary:Hydrogen sulfide can signal through 3 distinct mechanisms: ) reduction and/or direct binding of metalloprotein heme centers, ) serving as a potent antioxidant through reactive oxygen species/reactive nitrogen species scavenging, or ) post-translational modification of proteins by addition of a thiol (-SH) group onto reactive cysteine residues: a process known as persulfidation. Below toxic levels, hydrogen sulfide promotes mitochondrial biogenesis and function, thereby conferring protection against cellular stress. For these reasons, increases in hydrogen sulfide and hydrogen sulfide-producing enzymes have been implicated in several human disease states. This review will first summarize our current understanding of hydrogen sulfide production and metabolism, as well as its signaling mechanisms; second, this work will detail the known mechanisms of hydrogen sulfide in the mitochondria and the implications of its mitochondrial-specific impacts in several pathologic conditions.-Murphy, B., Bhattacharya, R., Mukherjee, P. Hydrogen sulfide signaling in mitochondria and disease.
ISSN:1530-6860
DOI:10.1096/fj.201901304R