Vitamin D deficiency, cardiac iron and cardiac function in thalassaemia major

• Published in: British journal of haematology Vol. 141; no. 6; pp. 891 - 894
• Main Authors: Wood, John C., Claster, Susan, Carson, Susan, Menteer, J. D., Hofstra, Thomas, Khanna, Rachna, Coates, Thomas
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.06.2008; Blackwell
• Subjects: Adolescent; Adult; Anemias. Hemoglobinopathies; beta-Thalassemia - complications; beta-Thalassemia - metabolism; beta-Thalassemia - physiopathology; beta-Thalassemia - therapy; Biological and medical sciences; Child; Child, Preschool; Diseases of red blood cells; Female; heart; Hematologic and hematopoietic diseases; Humans; Infant; Iron - analysis; Iron - metabolism; iron overload; Iron Overload - etiology; Iron Overload - metabolism; Liver - chemistry; magnetic resonance imaging; Male; Medical sciences; Metabolic diseases; Metals (hemochromatosis...); Myocardium - metabolism; Other metabolic disorders; Stroke Volume; thalassaemia major; Transfusion Reaction; Ventricular Dysfunction, Left - etiology; Ventricular Function, Left; vitamin D; Vitamin D Deficiency - complications; Vitamin D Deficiency - metabolism; Vitamin D Deficiency - physiopathology; Heart; Iron overload; Hemoglobinopathy; Cardiac performance; magnetic resonance imaging; Hematology; Iron deficiency anemia; Nutrition disorder; Metabolic diseases; Vitamin deficiency; Hemopathy; Iron; Inorganic element; Nuclear magnetic resonance imaging; Genetic disease; thalassaemia major; Hemolytic anemia; β-Thalassemia; Vitamin D; Medical imagery; Circulatory system; Malnutrition; Sideropenia; Nutritional status
• ISSN: 0007-1048; 1365-2141
• DOI: 10.1111/j.1365-2141.2008.07135.x

Summary Vitamin D25‐OH and D1‐25OH levels were compared with cardiac R2* (1/T2*), left ventricular ejection fraction (LVEF), age, ferritin and liver iron in 24 thalassaemia major patients. Vitamin D25‐OH levels were reduced in 13/24 patients while vitamin D1‐25OH levels were often elevated. Vitamin D25‐OH levels decreased with age (r2 = 0·48) and with liver iron (r2 = 0·20). Cardiac R2* was inversely related with the ratio of D25‐OH to D1‐25OH levels (r2 = 0·42). LVEF was also proportional to the D25‐OH/D1‐25OH ratio (r2 = 0·49). Vitamin D deficiency may be associated with cardiac iron uptake and ventricular dysfunction in thalassaemia major patients.