Near-Infrared Squaraine Dye as a Latent Ratiometric Fluorophore for the Detection of Aminothiol Content in Blood Plasma

Hunt for thiols: A nucleophilic thiol attack on a weakly fluorescent near‐infrared (NIR) squaraine dye results in a conjugation break to form an adduct that absorbs in the UV/Vis region and is highly fluorescent. This fluorophore allows the selective detection of thiols either by colorimetry or fluo...

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Published inAngewandte Chemie (International ed.) Vol. 47; no. 41; pp. 7883 - 7887
Main Authors Sreejith, Sivaramapanicker, Divya, Kizhumuri P, Ajayaghosh, Ayyappanpillai
Format Journal Article
LanguageEnglish
Published Weinheim Wiley-VCH Verlag 29.09.2008
WILEY-VCH Verlag
WILEY‐VCH Verlag
Wiley
Subjects
Amines - blood
Chemistry
Chemistry, Multidisciplinary
Cyclobutanes - chemistry
Fluorescent Dyes - chemistry
fluorophores
Humans
luminescence
molecular probes
Phenols - chemistry
Physical Sciences
Science & Technology
sensors
Spectroscopy, Near-Infrared
squaraine dyes
Sulfhydryl Compounds - blood
fluorophores
HOMOCYSTEINE
ION
CYSTEINE
SENSOR
ZINC
luminescence
sensors
CARDIOVASCULAR-DISEASE
CHEMISTRY
molecular probes
squaraine dyes
BAND-GAP POLYMERS
FLUORESCENT CHEMOSENSOR
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Summary:Hunt for thiols: A nucleophilic thiol attack on a weakly fluorescent near‐infrared (NIR) squaraine dye results in a conjugation break to form an adduct that absorbs in the UV/Vis region and is highly fluorescent. This fluorophore allows the selective detection of thiols either by colorimetry or fluorescence (see picture). The probe is suitable for the detection and estimation of the total aminothiol content in human blood plasma.
Bibliography:http://dx.doi.org/10.1002/anie.200803194
ark:/67375/WNG-RWMTMBTZ-8
We thank the Department of Science and Technology (DST), New Delhi Government of India for financial support. A.A. is a Ramanna Fellow of the DST. S.S. and K.P.D. thank the Council of Scientific and Industrial Research (CSIR), Government of India for research fellowships. We acknowledge S. Krishnan, Biotechnology Group, NIIST, Trivandrum for help with blood plasma analysis. This is entry No. NIIST-PPG-273.
istex:F10A162304B49DBEE8DC7A1840FBC119AAE5CE70
ArticleID:ANIE200803194
Government of India
Department of Science and Technology (DST)
We thank the Department of Science and Technology (DST), New Delhi Government of India for financial support. A.A. is a Ramanna Fellow of the DST. S.S. and K.P.D. thank the Council of Scientific and Industrial Research (CSIR), Government of India for research fellowships. We acknowledge S. Krishnan, Biotechnology Group, NIIST, Trivandrum for help with blood plasma analysis. This is entry No. NIIST‐PPG‐273.
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ISSN:1433-7851
1521-3773
1521-3773
DOI:10.1002/anie.200803194