Is there a special relationship between CD30-positive lymphoproliferative disorders and epidermal proliferation?

• Published in: Journal of cutaneous pathology Vol. 27; no. 6; pp. 271 - 275
• Main Authors: Cespedes, Yvana P., Rockley, Paul F., Flores, Frank, Ruiz, Phillip, Kaiser, Mark R., Elgart, George W.
• Format: Journal Article
• Language: English
• Published: Copenhagen Munksgaard International Publishers 01.07.2000; Blackwell
• Subjects: Aged; Antigens, CD - metabolism; Biological and medical sciences; Biopsy; Carcinoma, Squamous Cell - metabolism; Carcinoma, Squamous Cell - pathology; Dermatology; Female; Hematologic and hematopoietic diseases; Humans; Keratoacanthoma - metabolism; Keratoacanthoma - pathology; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis; Lymphoma, Large-Cell, Anaplastic - metabolism; Lymphoma, Large-Cell, Anaplastic - pathology; Lymphomatoid Papulosis - metabolism; Lymphomatoid Papulosis - pathology; Male; Medical sciences; Middle Aged; Skin - metabolism; Skin - pathology; Skin Neoplasms - metabolism; Skin Neoplasms - pathology; Tumors of the skin and soft tissue. Premalignant lesions; Human; Immunohistochemistry; Skin disease; Squamous cell carcinoma; Malignant hemopathy; Hemopathy; Malignant tumor; Non Hodgkin lymphoma; Keratoacanthoma; Case study; Lymphomatoid papulosis; Pathology; Concomitant disease; Cutaneous hematologic disease; Lymphoproliferative syndrome; Ki1 positive large cell anaplastic lymphoma; Adult; Clinical investigation; Skin; Benign neoplasm
• ISSN: 0303-6987; 1600-0560
• DOI: 10.1034/j.1600-0560.2000.027006271.x

The relationship between CD30+ lymphoma and epithelial proliferations is not well defined. CD30+ lymphoma and lymphomatoid papulos (LyP) share immunohistochemical epitopes and some other features. A single case of LyP associated with multiple keratoacanthomas (KAs) was recently reported. We report two cases of atypical lymphocytic proliferation with features of CD30+ lymphoma and LyP intimately associated to KA and squamous cell carcinoma (SCC), KA type. This similar combination of an epidermal tumor and apparent involvement with atypical lymphocytic infiltrates raises the possibility of an association between the two entities. We speculate that the association may be more than expected to occur by chance and suggest several mechanisms by which the association may evolve.