Reference values of cardiac volumes, dimensions, and new functional parameters by MR: A multicenter, multivendor study

• Published in: Journal of magnetic resonance imaging Vol. 45; no. 4; pp. 1055 - 1067
• Main Authors: Aquaro, Giovanni Donato, Camastra, Giovanni, Monti, Lorenzo, Lombardi, Massimo, Pepe, Alessia, Castelletti, Silvia, Maestrini, Viviana, Todiere, Giancarlo, Masci, Piergiorgio, Giovine, Gabriella, Barison, Andrea, Dellegrottaglie, Santo, Perazzolo Marra, Martina, Pontone, Gianluca, Di Bella, Gianluca
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.04.2017
• Subjects: Adolescent; Adult; Age; Age Factors; cardiac magnetic resonance imaging; Cardiac Volume - physiology; Confidence intervals; Diastole; Female; Females; Gender; Heart; Heart - diagnostic imaging; Heart - physiology; Heart - physiopathology; Heart diseases; Heart Ventricles - diagnostic imaging; Heart Ventricles - physiopathology; Humans; left ventricular global function index; longitudinal shortening; Magnetic resonance imaging; Magnetic Resonance Imaging, Cine - methods; Male; Males; Middle Aged; Normality; Precession; Reference Values; RV/LV EDV ratio; Sex differences; Sex Factors; sphericity index; Young Adult; reference values; sphericity index; cardiac magnetic resonance imaging; longitudinal shortening; left ventricular global function index; RV/LV EDV ratio
• ISSN: 1053-1807; 1522-2586
• DOI: 10.1002/jmri.25450

Purpose To define reference values of cardiac volumes, dimensions, and new morpho‐functional parameters normalized for age, gender, and body surface area by cine‐bSSFP (balanced steady‐state free‐precession) magnetic resonance (MR). Materials and Methods We enrolled 308 healthy subjects subdivided by gender and by six age classes: class I, >15–20 years; class II, >20–30 years; class III, >30–40 years; class IV, >40–50 years; class V, >50–60 years; and class VI >60 years. Dimensional, volumetric and morpho‐functional parameters of the left (LV) and right (RV) ventricles were measured using cine‐bSSFP MRI at 1.5T. Results The LV and RV end‐diastolic volume indexes (EDVi) were inversely related to age (P < 0.0001 r = –0.34 and P < 0.0001 r = –0.37, respectively). In addition, the LV mass index decreased with age (P = 0.0004, r = –0.21). The LV longitudinal shortening was not significantly different among groups: ≥15% in all populations (95% confidence interval [CI]: 16–31). The sphericity index measured in end‐diastole was higher in females than in males (P < 0.03): the upper limit was 40% for males and 42% for females. The normality cutoff of LV global function index was ≥33% in males and ≥35% in females. The end‐diastolic volume (EDV) of RV and LV was balanced (RV/LV ratio 0.85–1.15) without differences in the population. The LV EDV/mass was 1.0–1.8 in males and 1.0–2.1 in females. Conclusion This study provides potential age‐ and gender‐specific reference. Level of Evidence: 2 J. Magn. Reson. Imaging 2017;45:1055–1067