Association study of a functional promoter polymorphism of the X‐box binding protein 1 gene in Japanese patients with schizophrenia

• Published in: Psychiatry and clinical neurosciences Vol. 60; no. 5; pp. 633 - 635
• Main Authors: WATANABE, YUICHIRO, FUKUI, NAOKI, MURATAKE, TATSUYUKI, AMAGANE, HIDEKI, KANEKO, NAOSHI, NUNOKAWA, AYAKO, SOMEYA, TOSHIYUKI
• Format: Journal Article
• Language: English
• Published: Melbourne, Australia Blackwell Publishing Asia 01.10.2006; Blackwell Publishing
• Subjects: Adult; Adult and adolescent clinical studies; Alleles; Biological and medical sciences; Case-Control Studies; case‐control study; DNA-Binding Proteins - genetics; Female; Gene Frequency; Genetic factors; Genotype; Humans; Japan - epidemiology; Japanese people; Male; Medical sciences; Nuclear Proteins - genetics; Polymorphism, Genetic - genetics; Promoter Regions, Genetic - genetics; Psychiatric genetics; Psychiatric Status Rating Scales; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Psychoses; Regulatory Factor X Transcription Factors; Schizophrenia; Schizophrenia - epidemiology; Schizophrenia - genetics; Transcription Factors; X-Box Binding Protein 1; X‐box binding protein 1 (XBP1); Psychosis; Human; Binding protein; X-box binding protein 1 (XBPJ); Gene; case-control study; Schizophrenia; Genetics; Case control study; Genetic determinism; Japanese; Polymorphism
• ISSN: 1323-1316; 1440-1819
• DOI: 10.1111/j.1440-1819.2006.01570.x

The functional promoter polymorphism −116C/G of the X‐box binding protein 1 (XBP1) gene was found to be associated with schizophrenia in Han Chinese and Japanese subjects, although contradictive negative findings were also reported in European populations. To confirm this association in a Japanese population, the authors conducted a case‐control association study. There was no significant difference in both genotype and allele frequencies between the patients and control subjects, suggesting that the XBP1 –116C/G polymorphism might not confer increased susceptibility for schizophrenia in a Japanese population. However, further studies using a larger sample with detailed clinical data should be performed in several populations.