Serum brain‐derived neurotrophic factor levels in conversion disorder: Comparative study with depression

The aim of the present study was to compare serum brain‐derived neurotrophic factor (BDNF) levels of patients with major depressive disorder (MDD) and conversion disorder (CD). Serum BDNF levels were measured in the following three groups: 15 CD patients without any comorbid diagnosis of psychiatric...

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Published inPsychiatry and clinical neurosciences Vol. 61; no. 5; pp. 571 - 573
Main Authors DEVECI, ARTUNER, AYDEMIR, OMER, TASKIN, ORYAL, TANELI, FATMA, ESEN‐DANACI, AYSEN
Format Journal Article
LanguageEnglish
Published Melbourne, Australia Blackwell Publishing Asia 01.10.2007
Blackwell Publishing
Subjects
Adolescent
Adult
Adult and adolescent clinical studies
BDNF
Biological and medical sciences
biological marker
Biomarkers - blood
Brain-Derived Neurotrophic Factor - blood
conversion disorder
Conversion Disorder - blood
Conversion Disorder - psychology
Depression
Depressive Disorder, Major - blood
Depressive Disorder, Major - psychology
Female
Humans
Male
Medical sciences
Middle Aged
Mood disorders
Personality Inventory
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Reference Values
Somatoform disorders. Psychosomatics
stress
Stress, Psychological - blood
Stress, Psychological - complications
Mood disorder
BDNF
Somatoform disorder
Biological marker
Somatic conversion
Depression
Brain derived neurotrophic factor
Hysterical neurosis
Comparative study
Stress
conversion disorder
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ISSN1323-1316
1440-1819
DOI10.1111/j.1440-1819.2007.01710.x

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Summary:The aim of the present study was to compare serum brain‐derived neurotrophic factor (BDNF) levels of patients with major depressive disorder (MDD) and conversion disorder (CD). Serum BDNF levels were measured in the following three groups: 15 CD patients without any comorbid diagnosis of psychiatric disorder, 24 patients with MDD, and 26 healthy subjects without any psychiatric diagnosis or psychiatric treatment. The serum BDNF level of the healthy control group (31.4 ± 8.8 ng/mL) was statistically higher than the level of the MDD group (21.2 ± 11.3 ng/mL) and the CD group (24.3 ± 9.0 ng/mL; P = 0.008). This suggests that BDNF level may play a similar role in the pathophysiology of MDD and CD.
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ISSN:1323-1316
1440-1819
DOI:10.1111/j.1440-1819.2007.01710.x