A 3D Computational Head Model Under Dynamic Head Rotation and Head Extension Validated Using Live Human Brain Data, Including the Falx and the Tentorium

• Published in: Annals of biomedical engineering Vol. 47; no. 9; pp. 1923 - 1940
• Main Authors: Lu, Y.-C., Daphalapurkar, N. P., Knutsen, A. K., Glaister, J., Pham, D. L., Butman, J. A., Prince, J. L., Bayly, P. V., Ramesh, K. T.
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.09.2019; Springer Nature B.V; Springer
• Subjects: Anisotropy; Biochemistry; Biological and Medical Physics; Biomechanical Phenomena; Biomedical and Life Sciences; Biomedical Engineering and Bioengineering; Biomedicine; Biophysics; Brain; Brain - anatomy & histology; Brain - physiology; brain modeling; Classical Mechanics; Computation; Computational neuroscience; Construction materials; dynamic impact; Head; Head - anatomy & histology; Head - physiology; Head movement; Humans; in vivo experiments; Magnetic properties; Magnetic resonance imaging; Male; material point method; Mathematical models; Mechanical loading; Middle Aged; Models, Biological; RADIATION PROTECTION AND DOSIMETRY; Rotation; soft matter; State-of-the-Art Modeling and Simulation of the Brain's Response to Mechanical Loads; Substantia alba; tbi; Three dimensional models; validation; Validation; Brain modeling; TBI; experiments; In vivo experiments
• ISSN: 0090-6964; 1573-9686; 1573-9686
• DOI: 10.1007/s10439-019-02226-z

We employ an advanced 3D computational model of the head with high anatomical fidelity, together with measured tissue properties, to assess the consequences of dynamic loading to the head in two distinct modes: head rotation and head extension. We use a subject-specific computational head model, using the material point method, built from T1 magnetic resonance images, and considering the anisotropic properties of the white matter which can predict strains in the brain under large rotational accelerations. The material model now includes the shear anisotropy of the white matter. We validate the model under head rotation and head extension motions using live human data, and advance a prior version of the model to include biofidelic falx and tentorium. We then examine the consequences of incorporating the falx and tentorium in terms of the predictions from the computational head model.