Anticoagulant Activity of Sulfated Schizophyllan

Sulfated schizophylians with lower anticoagulant activity and higher anti-HIV activity were prepared. Those with sulfur contents above 6% showed anticoagulant activity irrespective of molecular weight. The activity was correlated with sulfur content. The triple helical structure of sulfated schizoph...

Full description

Saved in:
Bibliographic Details
Published inBioscience, biotechnology, and biochemistry Vol. 58; no. 2; pp. 406 - 407
Main Authors Hirata, Akio, Itoh, Wataru, Tabata, Kengo, Kojima, Takemasa, Itoyama, Shinji, Sugawara, Isamu
Format Journal Article
LanguageEnglish
Published Tokyo Taylor & Francis 1994
Japan Society for Bioscience Biotechnology and Agrochemistry
Oxford University Press
Subjects
Biological and medical sciences
General pharmacology
Medical sciences
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Pharmacognosy
Retroviridae
Basidiomycetes
Anticoagulant
In vitro
Sulfatation
Fungi
Virus
Schizophyllum commune
Structure activity relation
Plant origin
Organic sulfate
Lentivirinae
Antiviral
Human immunodeficiency virus
Polysaccharide
Thallophyta
Online AccessGet full text

Cover

More Information
Summary:Sulfated schizophylians with lower anticoagulant activity and higher anti-HIV activity were prepared. Those with sulfur contents above 6% showed anticoagulant activity irrespective of molecular weight. The activity was correlated with sulfur content. The triple helical structure of sulfated schizophylians did not affect their anticoagulant activity. A sulfated schizophyllan with a sulfur content of 5.0% showed low anticoagulant activity and good anti-HIV activity. These results indicate that the latter sulfated schizophyllan (sulfur content, 5%) would be useful as an anti-HIV agent for treatment of HIV-infected hemophiliacs.
ISSN:0916-8451
1347-6947
DOI:10.1271/bbb.58.406