Parathyroid tumors and related disorders

• Published in: Modern pathology Vol. 24; no. S2; pp. S78 - S93
• Main Author: DeLellis, Ronald A
• Format: Journal Article
• Language: English
• Published: New York Elsevier Inc 01.04.2011; Nature Publishing Group US; Elsevier Limited
• Subjects: 692/699/2743/1717; 692/699/67/1459; 692/700/139/422; 99mTc-sestamibi; Adenoma - genetics; Adenoma - pathology; Blood vessels; Bone diseases; carcinoma; Endocrine disorders; HPT-JT syndrome; Humans; Hypercalcemia; Hyperparathyroidism, Primary - genetics; Hyperparathyroidism, Primary - pathology; Hyperplasia; Intraoperative Period; Jaw Neoplasms - genetics; Jaw Neoplasms - pathology; Laboratory Medicine; long-course-article; Medicine; Medicine & Public Health; MEN-1; molecular diagnostics; Multiple Endocrine Neoplasia Type 1 - genetics; Multiple Endocrine Neoplasia Type 1 - pathology; parafibromin; Parathyroid Glands - pathology; Parathyroid Hormone - analysis; Parathyroid Neoplasms - genetics; Parathyroid Neoplasms - pathology; parathyromatosis; Pathology; Syndrome; Tumors; Rhode Island; United States > US; molecular diagnostics; HPT-JT syndrome; carcinoma; MEN-1; parathyromatosis; 99mTc-sestamibi; parafibromin; Tc-sestamibi
• ISSN: 0893-3952; 1530-0285
• DOI: 10.1038/modpathol.2010.132

Primary hyperparathyroidism (P-HPT) is a common endocrine disorder that occurs as a result of adenomas (80–85%), hyperplasias (10–15%) or carcinomas (<1%) of the parathyroid glands. Molecular genetic analyses of heritable P-HPT syndromes have provided considerable insight into the understanding of sporadic parathyroid tumors and hyperplasias. This review will focus on the criteria for classification of parathyroid proliferative disorders and will highlight our understanding of these lesions at the molecular level. Advances in radiological imaging techniques together with the rapid intraoperative parathyroid hormone assay will be reviewed with respect to current treatment approaches for P-HPT.