Objective methods for the assessment of the spinal and supraspinal effects of opioids

Highlights • Pupillometry is a sensitive measurement of opioid receptor activation in the CNS. • If more detailed information is needed on opioid activations at different levels of the CNS, EEG and fMRI methods may have potential. • Different methods provide complementary information.

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Bibliographic Details
Published inScandinavian journal of pain Vol. 14; no. 1; pp. 15 - 24
Main Authors Fischer, Iben W, Hansen, Tine M, Lelic, Dina, Brokjaer, Anne, Frøkjær, Jens, Christrup, Lona L, Olesen, Anne E
Format Journal Article
LanguageEnglish
Published Germany Elsevier B.V 01.01.2017
De Gruyter
Subjects
Analgesics, Opioid - pharmacology
Analgesics, Opioid - therapeutic use
Animals
Brain - drug effects
Brain - physiopathology
Humans
Internal Medicine
Objective methods
Opioids
Pain - drug therapy
Pain - physiopathology
Pain Medicine
Spinal Cord - drug effects
Spinal Cord - physiopathology
Spinal level
Supraspinal level
Supraspinal level
Objective methods
Spinal level
Opioids
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Summary:Highlights • Pupillometry is a sensitive measurement of opioid receptor activation in the CNS. • If more detailed information is needed on opioid activations at different levels of the CNS, EEG and fMRI methods may have potential. • Different methods provide complementary information.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:1877-8860
1877-8879
DOI:10.1016/j.sjpain.2016.10.001